(3R,10R)-10-Methyl-3-phenyl-6,9-dioxa-1,2,12-triaza-tricyclo[9.8.0.0^13,18]nonadeca-11,13⁽¹⁸⁾,14,16-tetraene-5,19-dione

Base Information

• Chemical Name: (3R,10R)-10-Methyl-3-phenyl-6,9-dioxa-1,2,12-triaza-tricyclo[9.8.0.0^13,18]nonadeca-11,13⁽¹⁸⁾,14,16-tetraene-5,19-dione
• CAS No.: 445397-19-3
• Molecular Formula: C₂₁H₂₁N₃O₄
• Molecular Weight: 379.415

Synonyms:(3R,10R)-10-Methyl-3-phenyl-6,9-dioxa-1,2,12-triaza-tricyclo[9.8.0.0^13,18]nonadeca-11,13⁽¹⁸⁾,14,16-tetraene-5,19-dione

Chemical Property of (3R,10R)-10-Methyl-3-phenyl-6,9-dioxa-1,2,12-triaza-tricyclo[9.8.0.0^13,18]nonadeca-11,13⁽¹⁸⁾,14,16-tetraene-5,19-dione

Chemical Property:

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Technology Process of (3R,10R)-10-Methyl-3-phenyl-6,9-dioxa-1,2,12-triaza-tricyclo[9.8.0.0^13,18]nonadeca-11,13⁽¹⁸⁾,14,16-tetraene-5,19-dione

There total 4 articles about (3R,10R)-10-Methyl-3-phenyl-6,9-dioxa-1,2,12-triaza-tricyclo[9.8.0.0^13,18]nonadeca-11,13⁽¹⁸⁾,14,16-tetraene-5,19-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C21H19N3O4 → (3R,10R)-10-Methyl-3-phenyl-6,9-dioxa-1,2,12-triaza-tricyclo[9.8.0.013,18]nonadeca-11,13(18),14,16-tetraene-5,19-dione (445397-19-3)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; tert-butyl alcohol;

DOI:10.1016/S0040-4039(02)00136-3

Reference yield:

(R)-2-(2-benzyloxyethoxy)propionic acid (445397-22-8) → (3R,10R)-10-Methyl-3-phenyl-6,9-dioxa-1,2,12-triaza-tricyclo[9.8.0.013,18]nonadeca-11,13(18),14,16-tetraene-5,19-dione (445397-19-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 62 percent / pyridine / CH₂Cl₂ / -20 - 20 °C

2: 95 percent / lead tetra-acetate; hexamethyldisilazane / CH₂Cl₂

3: 84 percent / samarium(II) iodide / tetrahydrofuran; 2-methyl-propan-2-ol

With pyridine; lead(IV) acetate; samarium diiodide; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;

DOI:10.1016/S0040-4039(02)00136-3

Reference yield:

(R)-3-amino-2-[1-(2-hydroxy-ethoxy)-ethyl]-3H-quinazolin-4-one (445397-14-8) → (3R,10R)-10-Methyl-3-phenyl-6,9-dioxa-1,2,12-triaza-tricyclo[9.8.0.013,18]nonadeca-11,13(18),14,16-tetraene-5,19-dione (445397-19-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / pyridine / CH₂Cl₂ / -20 - 20 °C

2: 95 percent / lead tetra-acetate; hexamethyldisilazane / CH₂Cl₂

3: 84 percent / samarium(II) iodide / tetrahydrofuran; 2-methyl-propan-2-ol

With pyridine; lead(IV) acetate; samarium diiodide; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;

DOI:10.1016/S0040-4039(02)00136-3

upstream raw materials:

(R)-2-(2-benzyloxyethoxy)propionic acid

(R)-3-amino-2-[1-(2-hydroxy-ethoxy)-ethyl]-3H-quinazolin-4-one

(R)-3-amino-2-[1-(2-hydroxyethoxy)ethyl]quinazolin-4-(3H)-one

Downstream raw materials:

methyl (3R)-3-amino-3-phenylpropanoate

(R)-3-{2-[(R)-1-(2-Hydroxy-ethoxy)-ethyl]-4-oxo-4H-quinazolin-3-ylamino}-3-phenyl-propionic acid methyl ester

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