4-[2-(tert-butyl-diphenyl-silanyloxy)-ethylidene]-2-triisopropylsilanyloxymethyl-6-trityloxymethyl-tetrahydropyran

Base Information

Chemical Name:4-[2-(tert-butyl-diphenyl-silanyloxy)-ethylidene]-2-triisopropylsilanyloxymethyl-6-trityloxymethyl-tetrahydropyran
CAS No.:184174-44-5
Molecular Formula:C₅₃H₆₈O₄Si₂
Molecular Weight:825.292
Hs Code.:

Synonyms:4-[2-(tert-butyl-diphenyl-silanyloxy)-ethylidene]-2-triisopropylsilanyloxymethyl-6-trityloxymethyl-tetrahydropyran

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Chemical Property of 4-[2-(tert-butyl-diphenyl-silanyloxy)-ethylidene]-2-triisopropylsilanyloxymethyl-6-trityloxymethyl-tetrahydropyran

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Technology Process of 4-[2-(tert-butyl-diphenyl-silanyloxy)-ethylidene]-2-triisopropylsilanyloxymethyl-6-trityloxymethyl-tetrahydropyran

There total 8 articles about 4-[2-(tert-butyl-diphenyl-silanyloxy)-ethylidene]-2-triisopropylsilanyloxymethyl-6-trityloxymethyl-tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 335119-61-4
2-(2-triisopropylsilanyloxymethyl-6-trityloxymethyl-tetrahydro-pyran-4-ylidene)-ethanol

: 184174-44-5
4-[2-(tert-butyl-diphenyl-silanyloxy)-ethylidene]-2-triisopropylsilanyloxymethyl-6-trityloxymethyl-tetrahydropyran

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;
DOI:10.1021/ol015551o

Reference yield: 86.0%

: {(2R,6S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-6-trityloxymethyl-tetrahydro-pyran-2-yl}-methanol

: 13154-24-0
triisopropylsilyl chloride

: 184174-44-5
4-[2-(tert-butyl-diphenyl-silanyloxy)-ethylidene]-2-triisopropylsilanyloxymethyl-6-trityloxymethyl-tetrahydropyran

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/ol061626i

Reference yield:

: tert-Butyl-{2-[(2R,6S)-2-(4-methoxy-benzyloxymethyl)-6-trityloxymethyl-tetrahydro-pyran-(4E)-ylidene]-ethoxy}-diphenyl-silane

: 184174-44-5
4-[2-(tert-butyl-diphenyl-silanyloxy)-ethylidene]-2-triisopropylsilanyloxymethyl-6-trityloxymethyl-tetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1: 297 mg / 2,3-dichloro-5,6-dicyanobenzoquinone; H₂O / CH₂Cl₂ / 1.25 h / 20 °C

2: 86 percent / imidazole / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol061626i