methyl 6-(benzyloxy)-1H-indole-2-carboxylate

Base Information

• Chemical Name: methyl 6-(benzyloxy)-1H-indole-2-carboxylate
• CAS No.: 103781-89-1
• Molecular Formula: C17H15 N O3
• Molecular Weight: 281.311
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90405823
• Wikidata: Q82210537
• Mol file: 103781-89-1.mol

Synonyms:methyl 6-(benzyloxy)-1H-indole-2-carboxylate;103781-89-1;METHYL 6-BENZYLOXYINDOLE-2-CARBOXYLATE;methyl 6-phenylmethoxy-1H-indole-2-carboxylate;MFCD04967027;6-Benzyloxy-1H-indole-2-carboxylic acid methyl ester;SCHEMBL8406972;DTXSID90405823;GSULHLQFRMLEEO-UHFFFAOYSA-N;AMY15388;STK504662;AKOS000124004;AS-38184;CS-0054137;METHYL6-BENZYLOXYINDOLE-2-CARBOXYLATE;EN300-44171;A909259;Z363993082

Chemical Property of methyl 6-(benzyloxy)-1H-indole-2-carboxylate

Chemical Property:

• Vapor Pressure: 4.31E-09mmHg at 25°C
• Refractive Index: 1.645
• Boiling Point: 472.3°C at 760 mmHg
• Flash Point: 239.5°C
• PSA: 51.32000
• Density: 1.253g/cm³
• LogP: 3.53350
• Storage Temp.: 2-8°C
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 281.10519334
• Heavy Atom Count: 21
• Complexity: 354

Purity/Quality:

97% ^*data from raw suppliers

Methyl6-(Benzyloxy)-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=CC2=C(N1)C=C(C=C2)OCC3=CC=CC=C3

Technology Process of methyl 6-(benzyloxy)-1H-indole-2-carboxylate

There total 3 articles about methyl 6-(benzyloxy)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 2-azido-3-(4-benzyloxyphenyl)-propenoate → 6-benzyloxy-1H-indole-2-carboxylic acid methyl ester (103781-89-1)

Guidance literature:

In xylene; for 2h; Heating; bath 210 deg C;

Reference yield:

methyl α-azido-4-(benzyloxy)cinnamate (115663-17-7) → 6-benzyloxy-1H-indole-2-carboxylic acid methyl ester (103781-89-1)

Guidance literature:

In xylene; for 7h; Yield given; Heating;

DOI:10.1021/jo00256a053

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → 6-benzyloxy-1H-indole-2-carboxylic acid methyl ester (103781-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₃ONa / methanol / 5 h / 0 °C

2: xylene / 7 h / Heating

With sodium methylate; In methanol; xylene;

DOI:10.1021/jo00256a053

upstream raw materials:

methyl α-azido-4-(benzyloxy)cinnamate

p-benzyloxybenzaldehyde

Downstream raw materials:

4,5-dihydro-3-(6-benzyloxyindol-2-ylcarbonyl)furan-2-one

6-benzyloxy-1-methyl-1H-indole-2-carboxylic acid methyl ester

1-(6-benzyloxyindol-2-yl)butane-1,4-dione

7-benzyloxy-1-methoxy-9H-carbazole