2-(2-(chloromethyl)allyl)-3-(phenylsulfanyl)-1-tosyl-1H-pyrrole

Base Information

• Chemical Name: 2-(2-(chloromethyl)allyl)-3-(phenylsulfanyl)-1-tosyl-1H-pyrrole
• CAS No.: 1447766-52-0
• Molecular Formula: C₂₁H₂₀ClNO₂S₂
• Molecular Weight: 417.98
• Mol file: 1447766-52-0.mol

Synonyms:2-(2-(chloromethyl)allyl)-3-(phenylsulfanyl)-1-tosyl-1H-pyrrole

Chemical Property of 2-(2-(chloromethyl)allyl)-3-(phenylsulfanyl)-1-tosyl-1H-pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-(2-(chloromethyl)allyl)-3-(phenylsulfanyl)-1-tosyl-1H-pyrrole

There total 2 articles about 2-(2-(chloromethyl)allyl)-3-(phenylsulfanyl)-1-tosyl-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-chloromethyl-3-trimethylsilyl-1-propene (18388-03-9) + 3-(phenylsulfinyl)-1-tosyl-1H-pyrrole (1447766-68-8) → 2-(2-(chloromethyl)allyl)-3-(phenylsulfanyl)-1-tosyl-1H-pyrrole (1447766-52-0)

Guidance literature:

With trifluoroacetic anhydride; In acetonitrile; at -40 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol401786d

Reference yield:

3-(phenylsulfanyl)-1-tosyl-1H-pyrrole (89597-74-0) → 2-(2-(chloromethyl)allyl)-3-(phenylsulfanyl)-1-tosyl-1H-pyrrole (1447766-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic anhydride / acetonitrile / -40 - 20 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane; acetonitrile; 2: |Claisen Rearrangement;

DOI:10.1021/ol401786d

upstream raw materials:

2-chloromethyl-3-trimethylsilyl-1-propene

3-(phenylsulfinyl)-1-tosyl-1H-pyrrole

3-(phenylsulfanyl)-1-tosyl-1H-pyrrole