2-[2-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenylamino}-methyl)-phenoxy]-octanoic acid ethyl ester

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Chemical Name:2-[2-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenylamino}-methyl)-phenoxy]-octanoic acid ethyl ester
CAS No.:188699-85-6
Molecular Formula:C₃₄H₃₇ClN₂O₃
Molecular Weight:557.132
Hs Code.:

Synonyms:2-[2-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenylamino}-methyl)-phenoxy]-octanoic acid ethyl ester

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Chemical Property of 2-[2-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenylamino}-methyl)-phenoxy]-octanoic acid ethyl ester

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Technology Process of 2-[2-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenylamino}-methyl)-phenoxy]-octanoic acid ethyl ester

There total 6 articles about 2-[2-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenylamino}-methyl)-phenoxy]-octanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 138286-76-7,5445-29-4
ethyl-2-bromooctanoate

: 177213-91-1
E-2-{3-[2-(7-chloroquinolin-2-yl)ethenyl]phenylaminomethyl}phenol

: 188699-85-6
2-[2-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenylamino}-methyl)-phenoxy]-octanoic acid ethyl ester

Guidance literature:: With potassium carbonate; In acetone; for 40h;
DOI:10.1016/S0968-0896(96)00253-2

Reference yield:

: 4965-33-7
2-methyl-7-chloroquinoline

: 188699-85-6
2-[2-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenylamino}-methyl)-phenoxy]-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / Ac₂O / 4.5 h / 130 °C

2: 94 percent / SnCl₂, HCl, AcOH / 1 h / 80 °C

3: diethyl ether / 2.5 h / Ambient temperature

4: NaBH₄, AcOH / ethanol / 12 h / Ambient temperature

5: 50 percent / K₂CO₃ / acetone / 40 h

With hydrogenchloride; sodium tetrahydroborate; acetic anhydride; potassium carbonate; acetic acid; tin(ll) chloride; In diethyl ether; ethanol; acetone;
DOI:10.1016/S0968-0896(96)00253-2

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 188699-85-6
2-[2-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenylamino}-methyl)-phenoxy]-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / Ac₂O / 4.5 h / 130 °C

2: 94 percent / SnCl₂, HCl, AcOH / 1 h / 80 °C

3: diethyl ether / 2.5 h / Ambient temperature

4: NaBH₄, AcOH / ethanol / 12 h / Ambient temperature

5: 50 percent / K₂CO₃ / acetone / 40 h

With hydrogenchloride; sodium tetrahydroborate; acetic anhydride; potassium carbonate; acetic acid; tin(ll) chloride; In diethyl ether; ethanol; acetone;
DOI:10.1016/S0968-0896(96)00253-2