2-{1-Methyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione

Base Information

• Chemical Name: 2-{1-Methyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione
• CAS No.: 184765-67-1
• Molecular Formula: C₂₂H₂₂N₄O₃
• Molecular Weight: 390.442

Synonyms:2-{1-Methyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione

Chemical Property of 2-{1-Methyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione

Chemical Property:

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Technology Process of 2-{1-Methyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione

There total 3 articles about 2-{1-Methyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{1-Methyl-2-[(E)-4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylimino]-ethyl}-isoindole-1,3-dione → 2-{1-Methyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione (184765-67-1)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; Yield given; Ambient temperature;

DOI:10.1248/cpb.44.2061

Reference yield:

2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal (73365-03-4,23101-87-3) → 2-{1-Methyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione (184765-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / methanol / 0.5 h / Ambient temperature

2: AcOH, NaBH₃CN / methanol / Ambient temperature

With sodium cyanoborohydride; acetic acid; In methanol;

DOI:10.1248/cpb.44.2061

Reference yield:

6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone (36725-28-7) → 2-{1-Methyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione (184765-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / methanol / 0.5 h / Ambient temperature

2: AcOH, NaBH₃CN / methanol / Ambient temperature

With sodium cyanoborohydride; acetic acid; In methanol;

DOI:10.1248/cpb.44.2061

upstream raw materials:

2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal

6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone

Downstream raw materials:

6-[4-(2-aminopropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

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