3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde

Base Information

Chemical Name:3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde
CAS No.:1612757-30-8
Molecular Formula:C₂₆H₂₅FN₂O₄
Molecular Weight:448.494
Hs Code.:

Synonyms:3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde

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Chemical Property of 3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde

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Technology Process of 3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde

There total 12 articles about 3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1612757-29-5
6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-1-{[[4-(3-hydroxyprop-1-ynyl)benzyl]oxy]methyl}pyrimidine-2,4(1H,3H)-dione

: 1612757-30-8
3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; at 80 ℃; for 12h;
DOI:10.1021/jm500139a

Reference yield:

: 1007895-03-5
1-iodo-4-(4-iodobenzyloxymethoxymethyl)benzene

: 1612757-30-8
3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.25 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere; Cooling

2.1: triethylamine / 0.5 h / Inert atmosphere

2.2: 3 h / Inert atmosphere

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 12 h / 80 °C

With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; acetonitrile; 2.1: |Sonogashira Cross-Coupling / 2.2: |Sonogashira Cross-Coupling;
DOI:10.1021/jm500139a

Reference yield:

: 1612757-28-4
6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyl-1-[[(4-iodobenzyl)oxy]methyl]pyrimidine-2,4(1H,3H)-dione

: 1612757-30-8
3-{4-[((6-((3,5-dimethylphenyl)fluoromethyl)-5-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)methyl]phenyl}propiolaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 0.5 h / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 12 h / 80 °C

With triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; 1.1: |Sonogashira Cross-Coupling / 1.2: |Sonogashira Cross-Coupling;
DOI:10.1021/jm500139a