3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-diiodo-dibenzofuran-4-yl]-propionic acid ethyl ester

Base Information

Chemical Name:3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-diiodo-dibenzofuran-4-yl]-propionic acid ethyl ester
CAS No.:475233-56-8
Molecular Formula:C₂₇H₂₅I₂NO₅
Molecular Weight:697.308
Hs Code.:

Synonyms:3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-diiodo-dibenzofuran-4-yl]-propionic acid ethyl ester

Suppliers and Price of 3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-diiodo-dibenzofuran-4-yl]-propionic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-diiodo-dibenzofuran-4-yl]-propionic acid ethyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-diiodo-dibenzofuran-4-yl]-propionic acid ethyl ester

There total 8 articles about 3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-diiodo-dibenzofuran-4-yl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 475233-55-7
3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-bis-trimethylsilanyl-dibenzofuran-4-yl]-propionic acid ethyl ester

: 475233-56-8
3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-diiodo-dibenzofuran-4-yl]-propionic acid ethyl ester

Guidance literature:: 3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-bis-trimethylsilanyl-dibenzofuran-4-yl]-propionic acid ethyl ester; With Iodine monochloride; potassium carbonate; In tetrachloromethane; at 0 ℃; for 1h;

With sodium hydrogensulfite; In tetrachloromethane; water; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/ja020675x

Reference yield:

: 132-64-9,214827-48-2
dibenzofuran

: 475233-56-8
3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-diiodo-dibenzofuran-4-yl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 70 percent / I₂; HIO₃; aq. H₂SO₄ / acetic acid; CCl₄ / 30 h / 65 °C

2.1: tert-butyllithium / tetrahydrofuran; diethyl ether; pentane / 5 h / -78 - 0 °C

2.2: 95 percent / tetrahydrofuran; diethyl ether; pentane / 24 h / 20 °C

3.1: sec-butyllithium; TMEDA / diethyl ether; pentane / 0.17 h / -78 °C

3.2: I₂ / diethyl ether; pentane / 24 h / 20 °C

3.3: 65 percent / NaHSO₃ / H₂O; diethyl ether; pentane

4.1: 60 percent / P(o-Tolyl)3; Et₃N; Pd(OAc)2 / dimethylformamide / 1 h / 80 °C

5.1: 90 percent / P(o-Tolyl)3; Et₃N; Pd(OAc)2 / dimethylformamide / 80 °C

6.1: 100 percent / H₂ / 10percent Pd/C / methanol / 16 h / 20 °C / 2585.81 Torr

7.1: 70 percent / DPPA; Et₃N / 24 h / Heating

8.1: K₂CO₃; ICl / CCl₄ / 1 h / 0 °C

8.2: 95 percent / NaHSO₃ / H₂O; CCl₄ / 1 h / 20 °C

With palladium diacetate; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; diphenyl-phosphinic acid; hydrogen; iodine; tert.-butyl lithium; sec.-butyllithium; Iodine monochloride; iodic acid; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; 10percent Pd/C; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; acetic acid; N,N-dimethyl-formamide; pentane; 4.1: Heck reaction / 5.1: Heck reaction / 7.1: Curtius rearangement;
DOI:10.1021/ja020675x

Reference yield:

: 5943-11-3
2,8-diiodo-dibenzo[b,d]furan

: 475233-56-8
3-[6-(2-benzyloxycarbonylamino-ethyl)-2,8-diiodo-dibenzofuran-4-yl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: tert-butyllithium / tetrahydrofuran; diethyl ether; pentane / 5 h / -78 - 0 °C

1.2: 95 percent / tetrahydrofuran; diethyl ether; pentane / 24 h / 20 °C

2.1: sec-butyllithium; TMEDA / diethyl ether; pentane / 0.17 h / -78 °C

2.2: I₂ / diethyl ether; pentane / 24 h / 20 °C

2.3: 65 percent / NaHSO₃ / H₂O; diethyl ether; pentane

3.1: 60 percent / P(o-Tolyl)3; Et₃N; Pd(OAc)2 / dimethylformamide / 1 h / 80 °C

4.1: 90 percent / P(o-Tolyl)3; Et₃N; Pd(OAc)2 / dimethylformamide / 80 °C

5.1: 100 percent / H₂ / 10percent Pd/C / methanol / 16 h / 20 °C / 2585.81 Torr

6.1: 70 percent / DPPA; Et₃N / 24 h / Heating

7.1: K₂CO₃; ICl / CCl₄ / 1 h / 0 °C

7.2: 95 percent / NaHSO₃ / H₂O; CCl₄ / 1 h / 20 °C

With palladium diacetate; N,N,N,N,-tetramethylethylenediamine; diphenyl-phosphinic acid; hydrogen; tert.-butyl lithium; sec.-butyllithium; Iodine monochloride; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; 10percent Pd/C; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; N,N-dimethyl-formamide; pentane; 3.1: Heck reaction / 4.1: Heck reaction / 6.1: Curtius rearangement;
DOI:10.1021/ja020675x