(4R)-3-{(2R)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4R)-3-{(2R)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one
CAS No.:770738-42-6
Molecular Formula:C₁₆H₂₁N₇O₃Si
Molecular Weight:387.473
Hs Code.:

Synonyms:(4R)-3-{(2R)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one

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Chemical Property of (4R)-3-{(2R)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one

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Technology Process of (4R)-3-{(2R)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one

There total 9 articles about (4R)-3-{(2R)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 770738-46-0
(4R)-3-{(2R)-2-azido-[(iodomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one

: 770738-42-6
(4R)-3-{(2R)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one

Guidance literature:: With N,N,N',N'-tetramethylguanidinium azide; In acetonitrile; at 23 ℃; for 48h;
DOI:10.1002/hlca.200490152

Reference yield:

: 770738-52-8
(4R)-3-{(2S)-3-[(azidomethyl)dimethylsilyl]-2-bromopropanoyl}-4-benzyl-1,3-oxazolidin-2-one

: (4R)-3-{(2S)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one

: 770738-42-6
(4R)-3-{(2R)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one

Guidance literature:: With N,N,N',N'-tetramethylguanidinium azide; In acetonitrile; at 0 ℃; for 4h; Title compound not separated from byproducts;
DOI:10.1002/hlca.200490152

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 770738-42-6
(4R)-3-{(2R)-2-azido-3-[(azidomethyl)dimethylsilyl]propanoyl}-4-benzyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: pivaloyl chloride; NaH / tetrahydrofuran / 2 h

1.2: 84 percent / BuLi / tetrahydrofuran; hexane / 4 h / -78 - 23 °C

2.1: 97 percent / NaI / acetone / 48 h / 65 °C

3.1: 94 percent / N,N,N',N'-tetramethylguanidinium azide / acetonitrile / 48 h / 23 °C

4.1: EtN(iPr)2; Bu₂BOTf / CH₂Cl₂ / 4 h / 0 °C

4.2: 62 percent / NBS / CH₂Cl₂ / 1 h / -78 °C

5.1: N,N,N',N'-tetramethylguanidinium azide / acetonitrile / 4 h / 0 °C

With N,N,N',N'-tetramethylguanidinium azide; di-n-butylboryl trifluoromethanesulfonate; pivaloyl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; dichloromethane; acetone; acetonitrile; 2.1: Finkelstein reaction;
DOI:10.1002/hlca.200490152