Technology Process of phenyl 3,4,6-tri-O-benzyl-β-D-mannopyranosyl-(1 → 2)-3,4,6-tri-O-benzyl-1-thio-α-D-mannopyranoside
There total 4 articles about phenyl 3,4,6-tri-O-benzyl-β-D-mannopyranosyl-(1 → 2)-3,4,6-tri-O-benzyl-1-thio-α-D-mannopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
L-Selectride;
In
tetrahydrofuran;
at -78 ℃;
for 0.833333h;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1039/c2ob26355f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve
1.2: 0.75 h / -40 °C / Inert atmosphere; Molecular sieve
2.1: sodium; methanol / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere
2.2: Amberlite IR-120 (H+)
3.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.75 h / -78 - 0 °C / Inert atmosphere
3.2: 0 °C / Inert atmosphere
4.1: L-Selectride / tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere
With
methanol; oxalyl dichloride; sodium; L-Selectride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane;
3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1039/c2ob26355f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium methylate / methanol; tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
1.2: Amberlite IR-120 (H+)
2.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve
2.2: 0.75 h / -40 °C / Inert atmosphere; Molecular sieve
3.1: sodium; methanol / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere
3.2: Amberlite IR-120 (H+)
4.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.75 h / -78 - 0 °C / Inert atmosphere
4.2: 0 °C / Inert atmosphere
5.1: L-Selectride / tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere
With
methanol; oxalyl dichloride; sodium methylate; sodium; L-Selectride; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; dichloromethane;
4.1: |Swern Oxidation / 4.2: |Swern Oxidation;
DOI:10.1039/c2ob26355f
