3β,21ξ-dimethoxy-20ξ-(hydroxymethyl)-14β,21-epoxy-16α-thiophenyl-5α-pregnane

Base Information

Chemical Name:3β,21ξ-dimethoxy-20ξ-(hydroxymethyl)-14β,21-epoxy-16α-thiophenyl-5α-pregnane
CAS No.:123849-45-6
Molecular Formula:C₃₀H₄₄O₄S
Molecular Weight:500.743
Hs Code.:

Synonyms:3β,21ξ-dimethoxy-20ξ-(hydroxymethyl)-14β,21-epoxy-16α-thiophenyl-5α-pregnane

Suppliers and Price of 3β,21ξ-dimethoxy-20ξ-(hydroxymethyl)-14β,21-epoxy-16α-thiophenyl-5α-pregnane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3β,21ξ-dimethoxy-20ξ-(hydroxymethyl)-14β,21-epoxy-16α-thiophenyl-5α-pregnane

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Technology Process of 3β,21ξ-dimethoxy-20ξ-(hydroxymethyl)-14β,21-epoxy-16α-thiophenyl-5α-pregnane

There total 12 articles about 3β,21ξ-dimethoxy-20ξ-(hydroxymethyl)-14β,21-epoxy-16α-thiophenyl-5α-pregnane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 123849-44-5
3β,21ξ-dimethoxy-14β,21-epoxy-20ξ-carboethoxy-16α-thiophenyl-5α-pregnane

: 123849-45-6
3β,21ξ-dimethoxy-20ξ-(hydroxymethyl)-14β,21-epoxy-16α-thiophenyl-5α-pregnane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Ambient temperature;
DOI:10.1016/S0040-4020(01)80082-X

Reference yield:

: 123849-39-8
3β-methoxy-5α,14β-androst-16-en-14-ol

: 123849-45-6
3β,21ξ-dimethoxy-20ξ-(hydroxymethyl)-14β,21-epoxy-16α-thiophenyl-5α-pregnane

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethylaniline / diethyl ether / 0.25 h

2: 45 percent / cupric chloride dihydrate, lithium chloride / dimethylformamide / 3 h / 100 °C

3: 1.) DIBAH / 1.) toluene; 2.) toluene, methanol, 15 min.

4: 78 percent / DIBAH / toluene / 0.17 h / -78 °C

5: 63 percent / BF₃*Et₂O / 12 h / Ambient temperature

6: 98 percent / lithiumaluminium hydride / tetrahydrofuran / 4 h / Ambient temperature

With lithium aluminium tetrahydride; boron trifluoride diethyl etherate; diisobutylaluminium hydride; N,N-dimethyl-aniline; lithium chloride; copper dichloride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)80082-X

Reference yield:

: 108-98-5
thiophenol

: 123849-45-6
3β,21ξ-dimethoxy-20ξ-(hydroxymethyl)-14β,21-epoxy-16α-thiophenyl-5α-pregnane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) DIBAH / 1.) toluene; 2.) toluene, methanol, 15 min.

2: 78 percent / DIBAH / toluene / 0.17 h / -78 °C

3: 63 percent / BF₃*Et₂O / 12 h / Ambient temperature

4: 98 percent / lithiumaluminium hydride / tetrahydrofuran / 4 h / Ambient temperature

With lithium aluminium tetrahydride; boron trifluoride diethyl etherate; diisobutylaluminium hydride; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(01)80082-X