Technology Process of 2-bromo-8-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine
There total 11 articles about 2-bromo-8-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methanol; sodium tetrahydroborate;
at 20 ℃;
for 2h;
Product distribution / selectivity;
- Guidance literature:
-
(rac)-8-(4-fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-2-amine;
With
sulfuric acid; sodium nitrite;
In
acetic acid;
at 10 - 20 ℃;
for 0.5h;
With
hydrogen bromide; copper(I) bromide;
In
sulfuric acid; water; acetic acid;
at 20 ℃;
for 1h;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 0.5 h / 160 °C / Microwave irradiation
2.1: 1,4-dioxane / 6 h / 20 °C
3.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol; methanol / 16.5 h / 20 °C / Reflux
4.1: hydrogenchloride; hydrogen / 5% Pd(II)/C(eggshell) / isopropyl alcohol; methanol / 25 °C
5.1: sodium nitrite; sulfuric acid / acetic acid / 0.5 h / 10 - 20 °C
5.2: 1 h / 20 °C
With
hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0); 5% Pd(II)/C(eggshell);
In
1,4-dioxane; methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;
