3‐methyl-2-(4‐(1-(2-morpholinoethyl)-1H‐pyrazol‐4-yl)phenyl)quinolin‐4(1H)‐one

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Chemical Name:3‐methyl-2-(4‐(1-(2-morpholinoethyl)-1H‐pyrazol‐4-yl)phenyl)quinolin‐4(1H)‐one
CAS No.:1361968-20-8
Molecular Formula:C₂₅H₂₆N₄O₂
Molecular Weight:414.507
Hs Code.:

Synonyms:3‐methyl-2-(4‐(1-(2-morpholinoethyl)-1H‐pyrazol‐4-yl)phenyl)quinolin‐4(1H)‐one

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Chemical Property of 3‐methyl-2-(4‐(1-(2-morpholinoethyl)-1H‐pyrazol‐4-yl)phenyl)quinolin‐4(1H)‐one

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Technology Process of 3‐methyl-2-(4‐(1-(2-morpholinoethyl)-1H‐pyrazol‐4-yl)phenyl)quinolin‐4(1H)‐one

There total 6 articles about 3‐methyl-2-(4‐(1-(2-morpholinoethyl)-1H‐pyrazol‐4-yl)phenyl)quinolin‐4(1H)‐one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 864754-18-7
4-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine

: 1361967-63-6
2-(4-bromophenyl)-3-methylquinolin-4(1H)-one

: 1361968-20-8
3‐methyl-2-(4‐(1-(2-morpholinoethyl)-1H‐pyrazol‐4-yl)phenyl)quinolin‐4(1H)‐one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 5h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00371

Reference yield: 87.0%

: 1003043-64-8
1-(2-morpholinoethyl)-1H-pyrazol-4-ylboronic acid

: 1361967-59-0
C₂₁H₂₁NO₃

: 1361968-20-8
3‐methyl-2-(4‐(1-(2-morpholinoethyl)-1H‐pyrazol‐4-yl)phenyl)quinolin‐4(1H)‐one

Guidance literature:: C₂₁H₂₁NO₃; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; Inert atmosphere;

1-(2-morpholinoethyl)-1H-pyrazol-4-ylboronic acid; In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;
DOI:10.1021/jm201184h

Reference yield:

: 63478-10-4
2-(2'-anilinyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

: 1361968-20-8
3‐methyl-2-(4‐(1-(2-morpholinoethyl)-1H‐pyrazol‐4-yl)phenyl)quinolin‐4(1H)‐one

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / butan-1-ol / 24 h / 130 °C / Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / Inert atmosphere

2.2: 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; water; butan-1-ol;
DOI:10.1021/jm201184h