N-[2-(2',3',4',6'-tetra-O-acetyl-α-D-mannopyranosyloxy)ethyl]-N(α)-(fluoren-9-ylmethoxycarbonyl)-S-(triphenylmethyl)-L-cysteine amide

Base Information

• Chemical Name: N-[2-(2',3',4',6'-tetra-O-acetyl-α-D-mannopyranosyloxy)ethyl]-N(α)-(fluoren-9-ylmethoxycarbonyl)-S-(triphenylmethyl)-L-cysteine amide
• CAS No.: 1187337-45-6
• Molecular Formula: C₅₃H₅₄N₂O₁₃S
• Molecular Weight: 959.083
• Mol file: 1187337-45-6.mol

Synonyms:N-[2-(2',3',4',6'-tetra-O-acetyl-α-D-mannopyranosyloxy)ethyl]-N(α)-(fluoren-9-ylmethoxycarbonyl)-S-(triphenylmethyl)-L-cysteine amide

Chemical Property of N-[2-(2',3',4',6'-tetra-O-acetyl-α-D-mannopyranosyloxy)ethyl]-N(α)-(fluoren-9-ylmethoxycarbonyl)-S-(triphenylmethyl)-L-cysteine amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(2',3',4',6'-tetra-O-acetyl-α-D-mannopyranosyloxy)ethyl]-N(α)-(fluoren-9-ylmethoxycarbonyl)-S-(triphenylmethyl)-L-cysteine amide

There total 1 articles about N-[2-(2',3',4',6'-tetra-O-acetyl-α-D-mannopyranosyloxy)ethyl]-N(α)-(fluoren-9-ylmethoxycarbonyl)-S-(triphenylmethyl)-L-cysteine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine (103213-32-7,167015-11-4) + 2-azidoethyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside (140428-83-7) → N-[2-(2',3',4',6'-tetra-O-acetyl-α-D-mannopyranosyloxy)ethyl]-N(α)-(fluoren-9-ylmethoxycarbonyl)-S-(triphenylmethyl)-L-cysteine amide (1187337-45-6)

Guidance literature:

With tributylphosphine; benzotriazol-1-ol; diisopropyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1002/ejoc.201000185

Reference yield: 92.0%

N-[2-(2',3',4',6'-tetra-O-acetyl-α-D-mannopyranosyloxy)ethyl]-N(α)-(fluoren-9-ylmethoxycarbonyl)-S-(triphenylmethyl)-L-cysteine amide (1187337-45-6) → N-[2-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)ethyl]-S-(triphenylmethyl)-L-cysteinamide (1234673-31-4)

Guidance literature:

With morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1055/s-0030-1258157

upstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine

2-azidoethyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside

Downstream raw materials:

N-[2-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)ethyl]-S-(triphenylmethyl)-L-cysteinamide