2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate

Base Information

Chemical Name:2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate
CAS No.:126937-44-8
Molecular Formula:C₂HF₃O₂*C₁₄H₁₈N₂O₄
Molecular Weight:392.332
Hs Code.:

Synonyms:2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate

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Chemical Property of 2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate

There total 8 articles about 2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 76-05-1
trifluoroacetic acid

: 126937-42-6,1211399-66-4
piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 2-methyl ester

: 126937-44-8
2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate

Guidance literature:: In dichloromethane; at 0 ℃; Inert atmosphere;

Reference yield:

: 98-97-5
2-pyrazylcarboxylic acid

: 126937-44-8
2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH, H₂ / 20percent Pd/C / H₂O / 2585.7 Torr

2: 50percent aq. NaOH / H₂O; dioxane / 3 h

3: 50percent aq. NaOH / 24 h / Ambient temperature

4: tetrahydrofuran

5: CF₃COOH / CH₂Cl₂

With sodium hydroxide; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0040-4039(01)93739-6

Reference yield:

: 4-(2-tert-Butoxy-acetyl)-piperazine-2-carboxylic acid

: 126937-44-8
2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 50percent aq. NaOH / 24 h / Ambient temperature

2: tetrahydrofuran

3: CF₃COOH / CH₂Cl₂

With sodium hydroxide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(01)93739-6