5′-(4,4′-dimethoxytrityl)-5-((4-phenyl)-1,2,3-triazol-1-yl)-2′-deoxyuridine

Base Information

• Chemical Name: 5′-(4,4′-dimethoxytrityl)-5-((4-phenyl)-1,2,3-triazol-1-yl)-2′-deoxyuridine
• CAS No.: 1574218-87-3
• Molecular Formula: C₃₈H₃₅N₅O₇
• Molecular Weight: 673.725

Synonyms:5′-(4,4′-dimethoxytrityl)-5-((4-phenyl)-1,2,3-triazol-1-yl)-2′-deoxyuridine

Chemical Property of 5′-(4,4′-dimethoxytrityl)-5-((4-phenyl)-1,2,3-triazol-1-yl)-2′-deoxyuridine

Chemical Property:

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Technology Process of 5′-(4,4′-dimethoxytrityl)-5-((4-phenyl)-1,2,3-triazol-1-yl)-2′-deoxyuridine

There total 3 articles about 5′-(4,4′-dimethoxytrityl)-5-((4-phenyl)-1,2,3-triazol-1-yl)-2′-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

5-azido-5′-(4,4′-dimethoxytrityl)-2′-deoxyuridine (1574218-86-2) + phenylacetylene (536-74-3) → 5′-(4,4′-dimethoxytrityl)-5-((4-phenyl)-1,2,3-triazol-1-yl)-2′-deoxyuridine (1574218-87-3)

Guidance literature:

With pyridine; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 3h;

DOI:10.1021/jo4025896

Reference yield:

5-azido-2′-deoxyuridine (137359-50-3) → 5′-(4,4′-dimethoxytrityl)-5-((4-phenyl)-1,2,3-triazol-1-yl)-2′-deoxyuridine (1574218-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 14 h / 20 °C / Inert atmosphere

2: pyridine; sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 3 h / 20 °C

With pyridine; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol;

DOI:10.1021/jo4025896

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5′-(4,4′-dimethoxytrityl)-5-((4-phenyl)-1,2,3-triazol-1-yl)-2′-deoxyuridine (1574218-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 14 h / 20 °C / Inert atmosphere

2: pyridine; sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 3 h / 20 °C

With pyridine; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol;

DOI:10.1021/jo4025896

upstream raw materials:

5-azido-5′-(4,4′-dimethoxytrityl)-2′-deoxyuridine

phenylacetylene

4,4'-dimethoxytrityl chloride

5-azido-2′-deoxyuridine

Downstream raw materials:

3′-O-(P-(2-cyanoethoxy)-N,N′-diisopropylaminophosphinyl)-5′-O-(4,4′-dimethoxytrityl)-5-((4-phenyl)-1,2,3-triazol-1-yl)-2′-deoxyuridine

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