p-Toluenesulfonate of 3β-Amino-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>4β-<<<(trichloroethoxy)carbonyl>oxy>acetoxy>azetidin-2-one

Base Information

Chemical Name:p-Toluenesulfonate of 3β-Amino-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>4β-<<<(trichloroethoxy)carbonyl>oxy>acetoxy>azetidin-2-one
CAS No.:74281-03-1
Molecular Formula:C₇H₈O₃S*C₂₀H₂₁Cl₃N₂O₈
Molecular Weight:695.959
Hs Code.:

Synonyms:p-Toluenesulfonate of 3β-Amino-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>4β-<<<(trichloroethoxy)carbonyl>oxy>acetoxy>azetidin-2-one

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Chemical Property of p-Toluenesulfonate of 3β-Amino-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>4β-<<<(trichloroethoxy)carbonyl>oxy>acetoxy>azetidin-2-one

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Technology Process of p-Toluenesulfonate of 3β-Amino-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>4β-<<<(trichloroethoxy)carbonyl>oxy>acetoxy>azetidin-2-one

There total 11 articles about p-Toluenesulfonate of 3β-Amino-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>4β-<<<(trichloroethoxy)carbonyl>oxy>acetoxy>azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 74280-99-2
7-<1-((Benzyloxy)carbonyl)-2-methylprop-1-enyl>-3-<<<(trichloroethoxy)carbonyl>oxy>methyl>-2-oxa-4,7-diazabicyclo<3.2.0>hept-3-en-6-one

: 104-15-4
toluene-4-sulfonic acid

: 74281-03-1
p-Toluenesulfonate of 3β-Amino-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>4β-<<<(trichloroethoxy)carbonyl>oxy>acetoxy>azetidin-2-one

Guidance literature:: In acetone; at 18 ℃; for 0.333333h;
DOI:10.1021/jo01306a028

Reference yield:

: 74280-93-6
1,2-secopenicillin tosylate

: 74281-03-1
p-Toluenesulfonate of 3β-Amino-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>4β-<<<(trichloroethoxy)carbonyl>oxy>acetoxy>azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / Et₃N / CH₂Cl₂ / 1) -40 deg C, 30 min, 2) up to 0 deg C, 30 min.

2: 9.30 g / Cl₂ / CH₂Cl₂; CCl₄ / 1) -78 deg C, 30 min, 2) 0 deg C, 30 min

3: 7.59 g / Ag₂O, AgBF₄ / CH₂Cl₂ / 1) -30 deg C, 2) -20 deg C, 1.5h

4: 92 percent / acetone / 0.33 h / 18 °C

With silver tetrafluoroborate; chlorine; triethylamine; silver(l) oxide; In tetrachloromethane; dichloromethane; acetone;
DOI:10.1021/jo01306a028

Reference yield:

: 73884-79-4
<<(Trichloroethoxy)carbonyl>oxy>acetyl Chloride

: 74281-03-1
p-Toluenesulfonate of 3β-Amino-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>4β-<<<(trichloroethoxy)carbonyl>oxy>acetoxy>azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / Et₃N / CH₂Cl₂ / 1) -40 deg C, 30 min, 2) up to 0 deg C, 30 min.

2: 9.30 g / Cl₂ / CH₂Cl₂; CCl₄ / 1) -78 deg C, 30 min, 2) 0 deg C, 30 min

3: 7.59 g / Ag₂O, AgBF₄ / CH₂Cl₂ / 1) -30 deg C, 2) -20 deg C, 1.5h

4: 92 percent / acetone / 0.33 h / 18 °C

With silver tetrafluoroborate; chlorine; triethylamine; silver(l) oxide; In tetrachloromethane; dichloromethane; acetone;
DOI:10.1021/jo01306a028