toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-vinyl ester

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Chemical Name:toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-vinyl ester
CAS No.:1312019-25-2
Molecular Formula:C₂₇H₂₆N₂O₆S₂
Molecular Weight:538.645
Hs Code.:

Synonyms:toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-vinyl ester

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Chemical Property of toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-vinyl ester

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Technology Process of toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-vinyl ester

There total 7 articles about toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-vinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethanone

: 4124-41-8
p-toluenesulfonylanhydride

: 1312019-25-2
toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-vinyl ester

Guidance literature:: 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-ethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

p-toluenesulfonylanhydride; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield:

: 130312-00-4
ethyl tetrahydro-4H-pyran-4-ylideneacetate

: 1312019-25-2
toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-vinyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 25 °C / 1551.49 Torr

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 °C / Reflux

2.2: 0 °C

3.1: pyridinium chlorochromate / dichloromethane / 5 h / 20 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

4.2: 1 h / -78 °C

5.1: Dess-Martin periodane / dichloromethane / 2 h / 25 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 1 h / -78 °C

With lithium aluminium tetrahydride; hydrogen; Dess-Martin periodane; pyridinium chlorochromate; lithium hexamethyldisilazane; lithium diisopropyl amide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 1312019-25-2
toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-4-yl)-vinyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetonitrile / 16 h / 20 - 70 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 25 °C / 1551.49 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 °C / Reflux

3.2: 0 °C

4.1: pyridinium chlorochromate / dichloromethane / 5 h / 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

5.2: 1 h / -78 °C

6.1: Dess-Martin periodane / dichloromethane / 2 h / 25 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

7.2: 1 h / -78 °C

With lithium aluminium tetrahydride; hydrogen; Dess-Martin periodane; pyridinium chlorochromate; lithium hexamethyldisilazane; lithium diisopropyl amide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;