tert-butyl 2-(4-hydroxyphenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate

Base Information

Chemical Name:tert-butyl 2-(4-hydroxyphenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate
CAS No.:1253955-04-2
Molecular Formula:C₂₃H₂₅N₃O₄
Molecular Weight:407.469
Hs Code.:

Synonyms:tert-butyl 2-(4-hydroxyphenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate

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Chemical Property of tert-butyl 2-(4-hydroxyphenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate

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Technology Process of tert-butyl 2-(4-hydroxyphenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate

There total 4 articles about tert-butyl 2-(4-hydroxyphenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253954-99-2
methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanoate

: 1253955-04-2
tert-butyl 2-(4-hydroxyphenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water

2: 1,2-dichloro-ethane; dmap

3: hydrazine / methanol / Reflux

4: tetrabutyl ammonium fluoride / tetrahydrofuran

With dmap; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; 1,2-dichloro-ethane; hydrazine; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2016.03.104

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1253955-04-2
tert-butyl 2-(4-hydroxyphenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 2,6-dimethylpyridine / dichloromethane

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water

4: 1,2-dichloro-ethane; dmap

5: hydrazine / methanol / Reflux

6: tetrabutyl ammonium fluoride / tetrahydrofuran

With 2,6-dimethylpyridine; dmap; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; 1,2-dichloro-ethane; lithium hexamethyldisilazane; hydrazine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2016.03.104

Reference yield:

: 243641-04-5
methyl 2-(4-(triisopropylsilyloxy)phenyl)acetate

: 1253955-04-2
tert-butyl 2-(4-hydroxyphenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water

3: 1,2-dichloro-ethane; dmap

4: hydrazine / methanol / Reflux

5: tetrabutyl ammonium fluoride / tetrahydrofuran

With dmap; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; 1,2-dichloro-ethane; lithium hexamethyldisilazane; hydrazine; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2016.03.104