6-(4-(methoxycarbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide

Base Information

• Chemical Name: 6-(4-(methoxycarbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide
• CAS No.: 1128075-63-7
• Molecular Formula: C₁₆H₁₄N₂O₃
• Molecular Weight: 282.299
• Mol file: 1128075-63-7.mol

Synonyms:6-(4-(methoxycarbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide

Chemical Property of 6-(4-(methoxycarbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide

Chemical Property:

Purity/Quality:

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Technology Process of 6-(4-(methoxycarbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide

There total 1 articles about 6-(4-(methoxycarbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide (332875-32-8) + 4-methoxycarbonylphenyl bromide (619-42-1) → 6-(4-(methoxycarbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide (1128075-63-7)

Guidance literature:

With palladium diacetate; caesium carbonate; DavePhos; Trimethylacetic acid; In toluene; at 110 ℃; for 15h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol900150u

Reference yield: 92.0%

6-(4-(methoxycarbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide (1128075-63-7) → methyl 4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-yl)benzoate (1128075-58-0)

Guidance literature:

With ammonium chloride; zinc; In tetrahydrofuran; water; for 0.333333h;

DOI:10.1021/ol900150u

upstream raw materials:

1-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide

4-methoxycarbonylphenyl bromide

Downstream raw materials:

methyl 4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-6-yl)benzoate