N-(2-fluoro-5-(((1S,2S)-1-hydroxy-3-methoxy-1-phenylpropan-2-yl)carbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-(2-fluoro-5-(((1S,2S)-1-hydroxy-3-methoxy-1-phenylpropan-2-yl)carbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426653-21-5
Molecular Formula:C₂₆H₂₅FN₄O₄
Molecular Weight:476.507
Hs Code.:

Synonyms:N-(2-fluoro-5-(((1S,2S)-1-hydroxy-3-methoxy-1-phenylpropan-2-yl)carbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-(2-fluoro-5-(((1S,2S)-1-hydroxy-3-methoxy-1-phenylpropan-2-yl)carbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-(2-fluoro-5-(((1S,2S)-1-hydroxy-3-methoxy-1-phenylpropan-2-yl)carbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine-3-carboxamide

There total 7 articles about N-(2-fluoro-5-(((1S,2S)-1-hydroxy-3-methoxy-1-phenylpropan-2-yl)carbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51594-34-4
(1S,2S)-2-amino-3-methoxy-1-phenyl-1-propanol

: 1426654-02-5
4-fluoro-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)benzoic acid

: 1426653-21-5
N-(2-fluoro-5-(((1S,2S)-1-hydroxy-3-methoxy-1-phenylpropan-2-yl)carbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: 4-fluoro-3-(7-methylimidazo[1,2-a]pyridine-3-carboxamido)benzoic acid; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

(1S,2S)-2-amino-3-methoxy-1-phenyl-1-propanol; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1426653-21-5
N-(2-fluoro-5-(((1S,2S)-1-hydroxy-3-methoxy-1-phenylpropan-2-yl)carbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 80 °C

2.1: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

3.2: 5 h / 50 °C

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C

5.1: HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 1 h / 20 °C

With oxalyl dichloride; sulfuric acid; palladium on activated charcoal; hydrogen; N,N-dimethyl-formamide; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1426653-21-5
N-(2-fluoro-5-(((1S,2S)-1-hydroxy-3-methoxy-1-phenylpropan-2-yl)carbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

2.2: 5 h / 50 °C

3.1: lithium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C

4.1: HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 1 h / 20 °C

With oxalyl dichloride; palladium on activated charcoal; hydrogen; N,N-dimethyl-formamide; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;