(2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran

Base Information

Chemical Name:(2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran
CAS No.:454474-94-3
Molecular Formula:C₃₉H₃₆O₅
Molecular Weight:584.712
Hs Code.:

Synonyms:(2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran

Suppliers and Price of (2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran

There total 6 articles about (2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 455253-63-1
(2R,3S,4S,5R)-3,4-di-benzyloxy-2-trityloxy-5-(hydroxymethyl)tetrahydrofuran

: 454474-94-3
(2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran

Guidance literature:: (2R,3S,4S,5R)-3,4-di-benzyloxy-2-trityloxy-5-(hydroxymethyl)tetrahydrofuran; With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; at -70 ℃; for 1h;

With triethylamine; In dichloromethane; dimethyl sulfoxide; at -70 - 0 ℃; Further stages.;
DOI:10.1021/jo020211h

Reference yield:

: 76-83-5
trityl chloride

: 454474-94-3
(2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1.1: 35.3 mg / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / 24 h / -20 - 20 °C

2.1: oxalyl chloride / CH₂Cl₂; dimethylsulfoxide / 1 h / -70 °C

2.2: 100 percent / triethylamine / CH₂Cl₂; dimethylsulfoxide / -70 - 0 °C

With 2,6-di-tert-butyl-4-methylpyridine; oxalyl dichloride; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo020211h

Reference yield:

: 41107-82-8
2,5-anhydro-D-mannitol

: 454474-94-3
(2S,3S,4S,5R)-3,4-di-benzyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 5 steps

1.1: 69 percent / pyridine / 19 h / 0 - 20 °C

2.1: 201 mg / NaH; n-Bu₄NI / dimethylformamide; various solvent(s) / 2 h / 0 °C

3.1: lithium aluminium hydride / diethyl ether / 2 h / 0 °C

4.1: 35.3 mg / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / 24 h / -20 - 20 °C

5.1: oxalyl chloride / CH₂Cl₂; dimethylsulfoxide / 1 h / -70 °C

5.2: 100 percent / triethylamine / CH₂Cl₂; dimethylsulfoxide / -70 - 0 °C

With pyridine; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methylpyridine; oxalyl dichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; In diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo020211h