12-(tert-butoxycarbonyl)-6,12-bis(-benzyloxy)-7-oxo-6,12-diazadodecanenitrile

Base Information

• Chemical Name: 12-(tert-butoxycarbonyl)-6,12-bis(-benzyloxy)-7-oxo-6,12-diazadodecanenitrile
• CAS No.: 144108-55-4
• Molecular Formula: C₂₉H₃₉N₃O₅
• Molecular Weight: 509.646
• Mol file: 144108-55-4.mol

Synonyms:12-(tert-butoxycarbonyl)-6,12-bis(-benzyloxy)-7-oxo-6,12-diazadodecanenitrile

Chemical Property of 12-(tert-butoxycarbonyl)-6,12-bis(-benzyloxy)-7-oxo-6,12-diazadodecanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-(tert-butoxycarbonyl)-6,12-bis(-benzyloxy)-7-oxo-6,12-diazadodecanenitrile

There total 3 articles about 12-(tert-butoxycarbonyl)-6,12-bis(-benzyloxy)-7-oxo-6,12-diazadodecanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Chlorovaleroyl chloride (1575-61-7) → 12-(tert-butoxycarbonyl)-6,12-bis(-benzyloxy)-7-oxo-6,12-diazadodecanenitrile (144108-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 1 N NaOH / CH₂Cl₂ / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) 80 deg C, overnight

With sodium hydroxide; sodium hydride; In dichloromethane;

DOI:10.1021/jm00103a012

Reference yield:

O-benzyl-N-(4-cyanobutyl)-hydroxylamine (112139-59-0) → 12-(tert-butoxycarbonyl)-6,12-bis(-benzyloxy)-7-oxo-6,12-diazadodecanenitrile (144108-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 1 N NaOH / CH₂Cl₂ / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) 80 deg C, overnight

With sodium hydroxide; sodium hydride; In dichloromethane;

DOI:10.1021/jm00103a012

Reference yield:

tert-butyl N-(benzyloxy)carbamate (79722-21-7) + N-(benzyloxy)-N-(4-cyanobutyl)-5-chloropentanamide (144108-54-3) → 12-(tert-butoxycarbonyl)-6,12-bis(-benzyloxy)-7-oxo-6,12-diazadodecanenitrile (144108-55-4)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 30 min, 2.) 80 deg C, overnight;

DOI:10.1021/jm00103a012

upstream raw materials:

tert-butyl N-(benzyloxy)carbamate

N-(benzyloxy)-N-(4-cyanobutyl)-5-chloropentanamide

5-Chlorovaleroyl chloride

O-benzyl-N-(4-cyanobutyl)-hydroxylamine

Downstream raw materials:

17-chloro-6,12-bis(benzyloxy)-7,13-dioxo-6,12-diazaheptadecanenitrile

6,12,18-tris(benzyloxy)-7,13-dioxo-6,12,18-triazaoctadecanenitrile

6,12,18-tris(benzyloxy)-7,13,19-trioxo-6,12,18-triazaeicosanenitrile

18-(tert-butoxycarbonyl)-6,12,18-tris(benzyloxy)-7,13-dioxo-6,12,18-triazaoctadecanenitrile