4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Base Information

• Chemical Name: 4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
• CAS No.: 950662-45-0
• Molecular Formula: C₂₃H₂₉ClN₄O₄SSi
• Molecular Weight: 521.112

Synonyms:4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Chemical Property of 4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

There total 13 articles about 4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-bromo-2-chloro-4-methoxy-5-methoxymethoxybenzene (950662-44-9) + 4-chloro-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (950661-72-0) → 4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (950662-45-0)

Guidance literature:

1-bromo-2-chloro-4-methoxy-5-methoxymethoxybenzene; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

4-chloro-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 1.508h;

Reference yield:

5-bromo-2-methoxyphenol (37942-01-1) → 4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (950662-45-0)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid; N-chloro-succinimide / acetonitrile / 16 h / 20 °C

2: phosphorus pentoxide / chloroform / 0 - 20 °C / Inert atmosphere

3: n-butyllithium; Triisopropyl borate / hexane; tetrahydrofuran / -78 - 20 °C / Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / N,N-dimethyl-formamide; water / 1.5 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-chloro-succinimide; n-butyllithium; Triisopropyl borate; phosphorus pentoxide; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; hexane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; 4: |Suzuki Coupling;

DOI:10.1016/j.bmc.2012.08.050

Reference yield:

4-chloro-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (950661-72-0) + C9H12BClO5 → 4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (950662-45-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.08.050

upstream raw materials:

1-bromo-2-chloro-4-methoxy-5-methoxymethoxybenzene

4-chloro-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-chloro-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine

2-(methylthio)-4-chloropyrrolo<2,3-d>pyrimidine

Downstream raw materials:

4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methanesulfonyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

2-[4-(2-chloro-5-hydroxy-4-methoxy-phenyl)-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]-N-isopropyl-acetamide

2-[4-(2-chloro-4,5-dimethoxy-phenyl)-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]-N-ethyl-acetamide

2-[4-(2-chloro-5-ethoxy-4-methoxy-phenyl)-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]-N-ethyl-acetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 950662-45-0 4-(2-chloro-4-methoxy-5-methoxymethoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send