benzyl [5-fluoro-2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Base Information

Chemical Name:benzyl [5-fluoro-2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate
CAS No.:502606-18-0
Molecular Formula:C₃₆H₃₃FN₂O₅
Molecular Weight:592.667
Hs Code.:

Synonyms:benzyl [5-fluoro-2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

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Chemical Property of benzyl [5-fluoro-2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

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Technology Process of benzyl [5-fluoro-2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

There total 7 articles about benzyl [5-fluoro-2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 603108-87-8
2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl chloride

: 1321938-46-8
C₁₈H₁₆FNO₂

: 502606-18-0
benzyl [5-fluoro-2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Guidance literature:: With tetrabutyl-ammonium chloride; sodium hydroxide; In dichloromethane; water; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2011.06.014

Reference yield:

: 502434-59-5
[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methyl 4-methylbenzenesulfonate

: 502606-18-0
benzyl [5-fluoro-2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C

2: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 50 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dimethoxyethane / 1 h / 40 °C

4: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane; water / 1 h / 20 °C

With oxalyl dichloride; tetrabutyl-ammonium chloride; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.06.014

Reference yield:

: 1321937-95-4
2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoic acid

: 502606-18-0
benzyl [5-fluoro-2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dimethoxyethane / 1 h / 40 °C

2: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane; water / 1 h / 20 °C

With oxalyl dichloride; tetrabutyl-ammonium chloride; N,N-dimethyl-formamide; sodium hydroxide; In 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/j.bmc.2011.06.014