C₂₂H₂₈O₂Si

Base Information

• Chemical Name: C₂₂H₂₈O₂Si
• CAS No.: 1255639-74-7
• Molecular Formula: C₂₂H₂₈O₂Si
• Molecular Weight: 352.549
• Mol file: 1255639-74-7.mol

Synonyms:C₂₂H₂₈O₂Si

Chemical Property of C₂₂H₂₈O₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₈O₂Si

There total 5 articles about C₂₂H₂₈O₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-3-(tert-butyldiphenylsiloxy)hex-5-en-1-ol (1255639-73-6) → C22H28O2Si (1255639-74-7)

Guidance literature:

(S)-3-(tert-butyldiphenylsiloxy)hex-5-en-1-ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ml1001807

Reference yield:

(S)-1-(tert-butyldimethylsiloxy)-3-(tert-butyldiphenylsiloxy)hex-5-ene (1255639-72-5) → C22H28O2Si (1255639-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; toluene-4-sulfonic acid / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With oxalyl dichloride; water; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 2.1: Swern oxidation / 2.2: Swern oxidation;

DOI:10.1021/ml1001807

Reference yield:

(3S)-1-[(tert-butyldimethylsilyl)oxy]hex-5-en-3-ol (127793-65-1) → C22H28O2Si (1255639-74-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 21 h / 20 °C / Inert atmosphere

2.1: water; toluene-4-sulfonic acid / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With 1H-imidazole; oxalyl dichloride; water; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3.1: Swern oxidation / 3.2: Swern oxidation;

DOI:10.1021/ml1001807

upstream raw materials:

(S)-1-(tert-butyldimethylsiloxy)-3-(tert-butyldiphenylsiloxy)hex-5-ene

(S)-3-(tert-butyldiphenylsiloxy)hex-5-en-1-ol

(3S)-1-[(tert-butyldimethylsilyl)oxy]hex-5-en-3-ol

C₂₉H₃₆O₂Si

Downstream raw materials:

C₃₉H₆₄O₃Si₃

C₄₈H₇₄O₇Si₃

C₄₈H₇₆O₇Si₃

C₄₁H₅₈O₆Si₂