(2R)-1-ACETYL-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: (2R)-1-ACETYL-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID
• CAS No.: 103476-80-8
• Molecular Formula: C11H11 N O3
• Molecular Weight: 205.213
• Hs Code.: 2933990090
• Mol file: 103476-80-8.mol

Synonyms:1H-Indole-2-carboxylicacid, 1-acetyl-2,3-dihydro-, (R)-; (R)-1-Acetylindoline-2-carboxylic acid

Chemical Property of (2R)-1-ACETYL-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.605
• Boiling Point: 494.1°Cat760mmHg
• PKA: 3.88±0.20(Predicted)
• Flash Point: 252.6°C
• PSA: 57.61000
• Density: 1.34g/cm³
• LogP: 1.11380

Purity/Quality:

98%min ^*data from raw suppliers

(2R)-1-ACETYL-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-1-ACETYL-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID

There total 8 articles about (2R)-1-ACETYL-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

N-acetyl-indoline-2-carboxylic acid methyl ester (110659-07-9) → 1-acetyl-2,3-indoline-2-carboxylic acid (103476-80-8) + (S)-N-acetyl-2,3-dihydroindoline-2-carboxylic acid methyl ester (110592-39-7)

Guidance literature:

In N,N-dimethyl-formamide;

Reference yield: 43.0%

N-acetyl-indoline-2-carboxylic acid methyl ester (110659-07-9) → 1-acetyl-2,3-indoline-2-carboxylic acid (103476-80-8)

Guidance literature:

at 24 ℃; Product distribution;

Reference yield:

N-acetyl-(S)-2,3-dihydro-1H-indole-2-carboxylic acid (82923-75-9) → 1-Acetyl-2,3-dihydro-1H-indole-2-carboxylic acid (10131-10-9,82923-75-9,82950-72-9,103476-80-8) + 1-Acetyl-2,3-dihydro-1H-indole-2-carboxylic acid (10131-10-9,82923-75-9,82950-72-9,103476-80-8)

Guidance literature:

resolved on CSP cellulose tris(3,5-dimethylphenylcarbamate) by chiral HPLC;

DOI:10.1246/cl.1988.1125

upstream raw materials:

N-acetyl-(S)-2,3-dihydro-1H-indole-2-carboxylic acid

N-acetyl-indoline-2-carboxylic acid methyl ester

Indole-2-carboxylic acid

N-acetyl-indole-2-carboxylic acid

Downstream raw materials:

1-acetyl-2,3-indoline-2-carboxylic acid

ethyl (R)-indoline-2-carboxylate hydrochloride

N-acetyl-(S)-2,3-dihydro-1H-indole-2-carboxylic acid

(R)-(-)-2,3-Dihydro-1H-Indole-2-Carboxylic Acid

Refernces

• 1、 Okamoto, Yoshio,Aburatani, Ryo,Kaida, Yuriko,Hatada, Koichi. "Direct Optical Resolution of Carboxylic Acids by Chyral HPLC on Tris(3,5-dimethylphenylcarbamate)s of Cellulose and Amylose". . p. 1125 - 1128. Retrieved 2007/10/02.
• 2、 Stanton,Gruenfeld,Babiarz,Ackerman,Friedmann,Yuan,Macchia. "Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives". . p. 1267 - 1277. Retrieved 2007/10/02.