2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoic acid

Base Information

Chemical Name:2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoic acid
CAS No.:627095-94-7
Molecular Formula:C₂₆H₃₄N₂O₄
Molecular Weight:438.567
Hs Code.:

Synonyms:2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoic acid

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Chemical Property of 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoic acid

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Technology Process of 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoic acid

There total 10 articles about 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1350846-85-3
methyl 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoate

: 627095-94-7
2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoic acid

Guidance literature:: methyl 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoate; With sodium hydroxide; In ethanol; at 20 ℃; for 5h;

With hydrogenchloride; In water;
DOI:10.1021/jm201306q

Reference yield:

: 1350846-97-7
methyl 2-[4-(2-phthalimidoethen-2-yl)phenoxy]-2-methylpropanoate

: 627095-94-7
2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: Wilkinson's catalyst; hydrogen / tetrahydrofuran; ethanol / 5 h / 20 °C / 3040.2 Torr

2.1: hydrazine hydrate / ethanol / 20 °C / Reflux

3.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 15 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

4.2: 0.5 h / Reflux; Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 18 h / 0 °C / Reflux

6.1: sodium hydroxide / ethanol / 5 h / 20 °C

With Wilkinson's catalyst; borane-THF; hydrazine hydrate; hydrogen; benzotriazol-1-ol; triethylamine; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm201306q

Reference yield:

: 1350846-81-9
methyl 2-[4-(2-heptanoylaminoethyl)phenoxy]-2-methylpropanoate

: 627095-94-7
2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 0.5 h / Reflux; Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 18 h / 0 °C / Reflux

3.1: sodium hydroxide / ethanol / 5 h / 20 °C

With borane-THF; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm201306q