4-{4-[(1-di-tert-butoxycarbonylamino-isoquinolin-6-ylamino)carboxymethyl]phenyl}butyric acid benzyl ester

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Chemical Name:4-{4-[(1-di-tert-butoxycarbonylamino-isoquinolin-6-ylamino)carboxymethyl]phenyl}butyric acid benzyl ester
CAS No.:943739-94-4
Molecular Formula:C₃₈H₄₃N₃O₈
Molecular Weight:669.775
Hs Code.:

Synonyms:4-{4-[(1-di-tert-butoxycarbonylamino-isoquinolin-6-ylamino)carboxymethyl]phenyl}butyric acid benzyl ester

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Chemical Property of 4-{4-[(1-di-tert-butoxycarbonylamino-isoquinolin-6-ylamino)carboxymethyl]phenyl}butyric acid benzyl ester

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Technology Process of 4-{4-[(1-di-tert-butoxycarbonylamino-isoquinolin-6-ylamino)carboxymethyl]phenyl}butyric acid benzyl ester

There total 2 articles about 4-{4-[(1-di-tert-butoxycarbonylamino-isoquinolin-6-ylamino)carboxymethyl]phenyl}butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 745020-22-8
imidodicarbonic acid 2-(6-amino-1-isoquinolinyl)-1,3-bis(1,1-dimethylethyl)ester

: 943739-92-2
4-(3-benzyloxycarbonylpropyl)phenylboronic acid

: 298-12-4
Glyoxilic acid

: 943739-94-4
4-{4-[(1-di-tert-butoxycarbonylamino-isoquinolin-6-ylamino)carboxymethyl]phenyl}butyric acid benzyl ester

Guidance literature:: In N,N-dimethyl-formamide; acetonitrile; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 4-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)phenyl]butyric acid

: 943739-94-4
4-{4-[(1-di-tert-butoxycarbonylamino-isoquinolin-6-ylamino)carboxymethyl]phenyl}butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / diethyl ether

1.2: pH 4

2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: 1,2-dichloro-ethane / 100 °C / Microwave irradiation

With potassium carbonate; sodium hydroxide; In diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00788

Reference yield: 80.0%

: 943739-94-4
4-{4-[(1-di-tert-butoxycarbonylamino-isoquinolin-6-ylamino)carboxymethyl]phenyl}butyric acid benzyl ester

: 26177-43-5
3-nitrobenzylamine hydrochloride

: 943739-95-5
4-{4-[(1-di-tert-butoxycarbonylamino-isoquinolin-6-ylamino)-(3-nitro-benzylcarbamoyl)-methyl]phenyl}butyric acid benzyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b00788