(2R,3S,4R,5R)-2-(2,6-dichlorobenzyloxymethyl)-5-iodomethyl-3-(4-methoxybenzyloxy)-4-methyltetrahydrofuran

Base Information

Chemical Name:(2R,3S,4R,5R)-2-(2,6-dichlorobenzyloxymethyl)-5-iodomethyl-3-(4-methoxybenzyloxy)-4-methyltetrahydrofuran
CAS No.:625822-01-7
Molecular Formula:C₂₂H₂₅Cl₂IO₄
Molecular Weight:551.249
Hs Code.:

Synonyms:(2R,3S,4R,5R)-2-(2,6-dichlorobenzyloxymethyl)-5-iodomethyl-3-(4-methoxybenzyloxy)-4-methyltetrahydrofuran

Suppliers and Price of (2R,3S,4R,5R)-2-(2,6-dichlorobenzyloxymethyl)-5-iodomethyl-3-(4-methoxybenzyloxy)-4-methyltetrahydrofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4R,5R)-2-(2,6-dichlorobenzyloxymethyl)-5-iodomethyl-3-(4-methoxybenzyloxy)-4-methyltetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4R,5R)-2-(2,6-dichlorobenzyloxymethyl)-5-iodomethyl-3-(4-methoxybenzyloxy)-4-methyltetrahydrofuran

There total 6 articles about (2R,3S,4R,5R)-2-(2,6-dichlorobenzyloxymethyl)-5-iodomethyl-3-(4-methoxybenzyloxy)-4-methyltetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 625821-98-9
(3S,4S,5R)-5,6-bis-(2,6-dichlorobenzyloxy)-4-(4-methoxybenzyloxy)-3-methylhex-1-ene

: 625822-01-7
(2R,3S,4R,5R)-2-(2,6-dichlorobenzyloxymethyl)-5-iodomethyl-3-(4-methoxybenzyloxy)-4-methyltetrahydrofuran

Guidance literature:: With iodine; In acetonitrile; at -20 ℃; for 3h;
DOI:10.1021/ol030101c

Reference yield:

: 625822-13-1
(R)-4-[(1S,2S)-1-(4-Methoxy-benzyloxy)-2-methyl-but-3-enyl]-2,2-dimethyl-[1,3]dioxolane

: 625822-01-7
(2R,3S,4R,5R)-2-(2,6-dichlorobenzyloxymethyl)-5-iodomethyl-3-(4-methoxybenzyloxy)-4-methyltetrahydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / p-TsOH / methanol

2: 92 percent / NaH; n-Bu₄NI / dimethylformamide / 20 °C

3: 87 percent / iodine / acetonitrile / 3 h / -20 °C

With iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo062396o

Reference yield:

: 88424-95-7
2,3-O-isopropylidene-1-C-<(1S)-1-methylprop-2-enyl>-D-erythro-glycerol

: 625822-01-7
(2R,3S,4R,5R)-2-(2,6-dichlorobenzyloxymethyl)-5-iodomethyl-3-(4-methoxybenzyloxy)-4-methyltetrahydrofuran

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / NaH / dimethylformamide

2: 85 percent / p-TsOH / methanol

3: 92 percent / NaH; n-Bu₄NI / dimethylformamide / 20 °C

4: 87 percent / iodine / acetonitrile / 3 h / -20 °C

With iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo062396o