2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide

Base Information

Chemical Name:2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide
CAS No.:1334764-07-6
Molecular Formula:C₂₇H₂₄N₆S
Molecular Weight:464.594
Hs Code.:

Synonyms:2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide

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Chemical Property of 2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide

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Technology Process of 2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide

There total 5 articles about 2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1334763-89-1
2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]-N-phenylacetamide

: 1334764-07-6
2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide

Guidance literature:: With Lawessons reagent; In 1,2-dimethoxyethane; at 85 ℃; for 12h;
DOI:10.1016/j.ejmech.2011.05.063

Reference yield:

: 108763-28-6
2,3-dimethylquinoxaline-6-carbaldehyde

: 1334764-07-6
2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tetrahydrofuran; isopropyl alcohol / 16 h / 20 °C

1.2: 1 h

1.3: pH 7 - 8

2.1: acetic acid / N,N-dimethyl-formamide / 2 h / 80 °C

2.2: 4 h / Reflux

3.1: sodium hydride; sodium iodide / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: Lawessons reagent / 1,2-dimethoxyethane / 12 h / 85 °C

With Lawessons reagent; sodium hydride; caesium carbonate; acetic acid; sodium iodide; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.ejmech.2011.05.063

Reference yield:

: 1334763-82-4
2-(2,3-dimethylquinoxalin-6-yl)-1-(6-methylpyridin-2-yl)ethanone

: 1334764-07-6
2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / N,N-dimethyl-formamide / 2 h / 80 °C

1.2: 4 h / Reflux

2.1: sodium hydride; sodium iodide / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: Lawessons reagent / 1,2-dimethoxyethane / 12 h / 85 °C

With Lawessons reagent; sodium hydride; acetic acid; sodium iodide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.05.063