di-tert-butyl (3R,3’R,5’R)-2-oxo-2’,3’-diphenylspiro-[indoline-3,4’-isoxazolidine]-1,5’-dicarboxylate

Base Information

Chemical Name:di-tert-butyl (3R,3’R,5’R)-2-oxo-2’,3’-diphenylspiro-[indoline-3,4’-isoxazolidine]-1,5’-dicarboxylate
CAS No.:1452777-13-7
Molecular Formula:C₃₂H₃₄N₂O₆
Molecular Weight:542.632
Hs Code.:

Synonyms:di-tert-butyl (3R,3’R,5’R)-2-oxo-2’,3’-diphenylspiro-[indoline-3,4’-isoxazolidine]-1,5’-dicarboxylate

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Chemical Property of di-tert-butyl (3R,3’R,5’R)-2-oxo-2’,3’-diphenylspiro-[indoline-3,4’-isoxazolidine]-1,5’-dicarboxylate

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Technology Process of di-tert-butyl (3R,3’R,5’R)-2-oxo-2’,3’-diphenylspiro-[indoline-3,4’-isoxazolidine]-1,5’-dicarboxylate

There total 11 articles about di-tert-butyl (3R,3’R,5’R)-2-oxo-2’,3’-diphenylspiro-[indoline-3,4’-isoxazolidine]-1,5’-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1222871-91-1
(E)-tert-butyl 3-(2-(tert-butoxy)-2-oxoethylidene)-2-oxoindoline-1-carboxylate

: 1137-96-8,26505-49-7,201024-81-9
N-(benzylidene)aniline N-oxide

: 1452777-13-7
di-tert-butyl (3R,3’R,5’R)-2-oxo-2’,3’-diphenylspiro-[indoline-3,4’-isoxazolidine]-1,5’-dicarboxylate

Guidance literature:: (E)-tert-butyl 3-(2-(tert-butoxy)-2-oxoethylidene)-2-oxoindoline-1-carboxylate; With (1R,1'R,2S,2'S)-1,1'-(propane-1,3-diyl)bis(2-((2,6-diisopropylphenyl)carbamoyl)pyrrolidine-1-oxide); cobalt(II) tetrafluoroborate hexahydrate; In ethyl acetate; at 30 ℃; for 0.5h; Inert atmosphere;

N-(benzylidene)aniline N-oxide; In ethyl acetate; at 0 ℃; for 72h; Solvent; stereoselective reaction; Inert atmosphere;
DOI:10.1039/c7cc03575f

Reference yield:

: 1448777-86-3
C₁₉H₂₃NO₅

: 1137-96-8,26505-49-7,201024-81-9
N-(benzylidene)aniline N-oxide

: C₃₂H₃₄N₂O₆

: 1452777-13-7
di-tert-butyl (3R,3’R,5’R)-2-oxo-2’,3’-diphenylspiro-[indoline-3,4’-isoxazolidine]-1,5’-dicarboxylate

Guidance literature:: With 1,1’-((1R,2R)-cyclohexane-1,2-diyl)bis(3-(3,5-bis(trifluoromethyl)phenyl) thiourea); In hexane; at -10 ℃; for 48h; Overall yield = 70 %; enantioselective reaction;
DOI:10.1002/chem.201202937

Reference yield:

: 1222871-91-1
(E)-tert-butyl 3-(2-(tert-butoxy)-2-oxoethylidene)-2-oxoindoline-1-carboxylate

: 1137-96-8,26505-49-7,201024-81-9
N-(benzylidene)aniline N-oxide

: 1452777-13-7
di-tert-butyl (3R,3’R,5’R)-2-oxo-2’,3’-diphenylspiro-[indoline-3,4’-isoxazolidine]-1,5’-dicarboxylate

: di-tert-butyl (3S,3’S,5’S)-2-oxo-2’,3’-diphenylspiro-[indoline-3,4’-isoxazolidine]-1,5’-dicarboxylate

Guidance literature:: (E)-tert-butyl 3-(2-(tert-butoxy)-2-oxoethylidene)-2-oxoindoline-1-carboxylate; With C₃₉H₆₀N₄O₄; cobalt(II) tetrafluoroborate hexahydrate; In toluene; at 30 ℃; for 0.5h; Inert atmosphere;

N-(benzylidene)aniline N-oxide; In toluene; at 0 ℃; for 72h; Reagent/catalyst; Solvent; Overall yield = 90 %; stereoselective reaction; Inert atmosphere;
DOI:10.1039/c7cc03575f