6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one

Base Information

• Chemical Name: 6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one
• CAS No.: 1161924-84-0
• Molecular Formula: C₁₆H₁₄F₄N₂O
• Molecular Weight: 326.294

Synonyms:6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one

Chemical Property of 6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one

There total 1 articles about 6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5,5-dimethyl-2-(2,2,2-trifluoroacetyl)cyclohexane-1,3-dione (893842-26-7) + 4-fluorophenyhydrazine hydrochloride (823-85-8) → 6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one (1161924-84-0)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 8h;

DOI:10.1134/S1070363208100241

Reference yield: 95.0%

6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one (1161924-84-0) → (E)-6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one oxime

Guidance literature:

With pyridine; hydroxylamine hydrochloride; for 3h; diastereoselective reaction; Reflux;

DOI:10.1134/S1070428015050115

Reference yield: 73.0%

6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one (1161924-84-0) → 7-bromo-1-(4-fluorophenyl)-6,6-dimethyl-3-trifluoromethyl-6,7-dihydro-1H-indazol-4(5H)-one (1373316-13-2)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 8h; Reflux;

DOI:10.1134/S1070428012030128

upstream raw materials:

5,5-dimethyl-2-(2,2,2-trifluoroacetyl)cyclohexane-1,3-dione

4-fluorophenyhydrazine hydrochloride

Downstream raw materials:

7-bromo-1-(4-fluorophenyl)-6,6-dimethyl-3-trifluoromethyl-6,7-dihydro-1H-indazol-4(5H)-one

7,7-dibromo-1-(4-fluorophenyl)-6,6-dimethyl-3-trifluoromethyl-6,7-dihydro-1H-indazol-4(5H)-one

3-(4-fluorophenyl)-5,5-dimethyl-1-trifluoromethyl-4,5-dihydro-3H-pyrazolo[4,3-a]phenazine

2,6-bis(4-fluorophenyl)-4,4-dimethyl-8-trifluoromethyl-3,4,5,6-tetrahydroimidazo[4,5-e]indazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1161924-84-0 6,6-dimethyl-3-trifluoromethyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send