1,2,3,4-Tetrahydronaphthalene-2,7-diamine

Base Information

• Chemical Name: 1,2,3,4-Tetrahydronaphthalene-2,7-diamine
• CAS No.: 103393-75-5
• Molecular Formula: C10H14 N2
• Molecular Weight: 162.235
• Hs Code.: 2921590090
• DSSTox Substance ID: DTXSID70564184
• Mol file: 103393-75-5.mol

Synonyms:103393-75-5;1,2,3,4-TETRAHYDRO-NAPHTHALENE-2,7-DIAMINE;1,2,3,4-Tetrahydronaphthalene-2,7-diamine;SCHEMBL9752112;DTXSID70564184;AKOS006292902;SB30301;CS-0440265;EN300-133639;2,2,3,4,4,5,6-HEPTABROMODIPHENYLETHER;A896473

Chemical Property of 1,2,3,4-Tetrahydronaphthalene-2,7-diamine

Chemical Property:

• PSA: 52.04000
• LogP: 2.36630
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 162.115698455
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

1,2,3,4-Tetrahydro-naphthalene-2,7-diamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(CC1N)C=C(C=C2)N

Technology Process of 1,2,3,4-Tetrahydronaphthalene-2,7-diamine

There total 7 articles about 1,2,3,4-Tetrahydronaphthalene-2,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

N-(7-amino-1,2,3,4-tetrahydro-2-naphthalenyl)-2,2,2-trifluoroacetamide (188412-42-2) + C12H13F3N2O → 1,2,3,4-tetrahydronaphthalene-2,6-diamine (129884-89-5) + 1,2,3,4-tetrahydronaphthalene-2,7-diamine (103393-75-5)

Guidance literature:

With ammonium hydroxide; potassium carbonate; In ethanol; at 90 ℃; for 5h;

Reference yield:

1,2,3,4-tetrahydronaphthalen-2-one (530-93-8) → 1,2,3,4-tetrahydronaphthalene-2,7-diamine (103393-75-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium formate; palladium 10% on activated carbon / methanol; water / 16 h / 40 °C

2.1: dmap; triethylamine / dichloromethane / 20 °C / Cooling with ice

3.1: nitric acid; nitromethane; sulfuric acid / water / 2.5 h / -5 - 0 °C

3.2: 16 h / 20 °C / 760.05 Torr

4.1: potassium carbonate; ammonium hydroxide / ethanol / 5 h / 90 °C

With dmap; ammonium hydroxide; nitromethane; sulfuric acid; palladium 10% on activated carbon; nitric acid; ammonium formate; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water;

Reference yield:

2-trifluoroacetylamino-1,2,3,4-tetrahydro-naphthalene (38389-79-6) → 1,2,3,4-tetrahydronaphthalene-2,7-diamine (103393-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: nitric acid; nitromethane; sulfuric acid / water / 2.5 h / -5 - 0 °C

1.2: 16 h / 20 °C / 760.05 Torr

2.1: potassium carbonate; ammonium hydroxide / ethanol / 5 h / 90 °C

With ammonium hydroxide; nitromethane; sulfuric acid; nitric acid; potassium carbonate; In ethanol; water;

upstream raw materials:

2,7-diaminonaphthalene

i-Amyl alcohol

1,2,3,4-tetrahydronaphthalen-2-one

2-trifluoroacetylamino-1,2,3,4-tetrahydro-naphthalene

Downstream raw materials:

7-OH-AT