⁽¹⁸⁾F-N-(3-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide

Base Information

• Chemical Name: ⁽¹⁸⁾F-N-(3-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide
• CAS No.: 1351410-70-2
• Molecular Formula: C₁₉H₂₉FN₄O
• Molecular Weight: 347.465

Synonyms:⁽¹⁸⁾F-N-(3-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide

Chemical Property of ⁽¹⁸⁾F-N-(3-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of ⁽¹⁸⁾F-N-(3-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide

There total 5 articles about ⁽¹⁸⁾F-N-(3-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-(4-(6-nitropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide (1351411-90-9) → (18)F-N-(3-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide (1351410-70-2)

Guidance literature:

With [KC₂₂₂]⁺¹⁸F^-; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 150 ℃; for 0.25h; Inert atmosphere;

Reference yield:

N-(3-(4-benzylpiperazin-1-yl)propyl)cyclohexanecarboxamide (1259172-46-7) → (18)F-N-(3-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide (1351410-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; acetic acid / palladium 10% on activated carbon / water / 4 h / 60 °C / 1551.49 Torr

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 120 °C / Microwave irradiation

3: [KC₂₂₂]⁺¹⁸F^- / N,N-dimethyl-formamide; dimethyl sulfoxide / 0.25 h / 150 °C / Inert atmosphere

With hydrogenchloride; [KC₂₂₂]⁺¹⁸F^-; acetic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

1-(3-amino-1-propyl)-4-(phenylmethyl)piperazine (4553-27-9) → (18)F-N-(3-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide (1351410-70-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: hydrogenchloride; acetic acid / palladium 10% on activated carbon / water / 4 h / 60 °C / 1551.49 Torr

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 120 °C / Microwave irradiation

4: [KC₂₂₂]⁺¹⁸F^- / N,N-dimethyl-formamide; dimethyl sulfoxide / 0.25 h / 150 °C / Inert atmosphere

With hydrogenchloride; [KC₂₂₂]⁺¹⁸F^-; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

N-(3-(4-benzylpiperazin-1-yl)propyl)cyclohexanecarboxamide

N-(3-(piperazin-1-yl)propyl)cyclohexanecarboxamide

N-(3-(4-(6-nitropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide

1-(3-amino-1-propyl)-4-(phenylmethyl)piperazine

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