Fmoc-His(Trt)-aldehyde

Base Information

Chemical Name:Fmoc-His(Trt)-aldehyde
CAS No.:170852-97-8
Molecular Formula:C₄₀H₃₃N₃O₃
Molecular Weight:603.72
Hs Code.:

Synonyms:Fmoc-His(Trt)-aldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Fmoc-His(Trt)-aldehyde

Chemical Property:

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Technology Process of Fmoc-His(Trt)-aldehyde

There total 2 articles about Fmoc-His(Trt)-aldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 170852-98-9
Fmoc-His(Trt)-N(Me)OMe

: 170852-97-8
Fmoc-His(Trt)-aldehyde

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/j.bmcl.2010.09.054

Reference yield:

: 109425-51-6
Fmoc-His(Trt)-OH

: 170852-97-8
Fmoc-His(Trt)-aldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 3 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C

With lithium aluminium tetrahydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm101425m