FMOC-CYS(BZL)-CL

Base Information

• Chemical Name: FMOC-CYS(BZL)-CL
• CAS No.: 103321-55-7
• Molecular Formula: C25H22 Cl N O3 S
• Molecular Weight: 451.97
• Mol file: 103321-55-7.mol

Synonyms:Carbamicacid, [2-chloro-2-oxo-1-[[(phenylmethyl)thio]methyl]ethyl]-,9H-fluoren-9-ylmethyl ester, (S)-

Chemical Property of FMOC-CYS(BZL)-CL

Chemical Property:

• Boiling Point: 627.7±55.0 °C(Predicted)
• PKA: 9.97±0.46(Predicted)
• PSA: 80.70000
• Density: 1.299±0.06 g/cm3(Predicted)
• LogP: 5.98340

Purity/Quality:

98.5% ^*data from raw suppliers

Fmoc-Cys(Bzl)-Cl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fmoc-Cys(Bzl)-Cl is used as a reactant in the solution phase synthesis of peptides.

Technology Process of FMOC-CYS(BZL)-CL

There total 1 articles about FMOC-CYS(BZL)-CL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

Nα-Fmoc-S-benzylcysteine (53298-33-2,252049-18-6) → Fmoc-Cys(Bzl)-Cl (103321-55-7)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jo00369a042

Reference yield: 83.0%

(S)-2-amino-3-phenylpropionamide hydrochloride (65864-22-4) + Fmoc-Cys(Bzl)-Cl (103321-55-7) → Fmoc-Cys(Bzl)-Phe-NH2

Guidance literature:

With Indion 830S anion exchange resin; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1007/s10989-012-9337-5

upstream raw materials:

N^α-Fmoc-S-benzylcysteine