diethyl (3-(N-(benzyloxy)acetamido)-1-(3'-methyl-[1,1'-biphenyl]-4-yl)propyl)phosphonate

Base Information

Chemical Name:diethyl (3-(N-(benzyloxy)acetamido)-1-(3'-methyl-[1,1'-biphenyl]-4-yl)propyl)phosphonate
CAS No.:1339075-32-9
Molecular Formula:C₂₉H₃₆NO₅P
Molecular Weight:509.582
Hs Code.:

Synonyms:diethyl (3-(N-(benzyloxy)acetamido)-1-(3'-methyl-[1,1'-biphenyl]-4-yl)propyl)phosphonate

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Chemical Property of diethyl (3-(N-(benzyloxy)acetamido)-1-(3'-methyl-[1,1'-biphenyl]-4-yl)propyl)phosphonate

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Technology Process of diethyl (3-(N-(benzyloxy)acetamido)-1-(3'-methyl-[1,1'-biphenyl]-4-yl)propyl)phosphonate

There total 8 articles about diethyl (3-(N-(benzyloxy)acetamido)-1-(3'-methyl-[1,1'-biphenyl]-4-yl)propyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1339075-26-1
diethyl (3-(N-(benzyloxy)acetamido)-1-(4-bromophenyl)-propyl)phosphonate

: 17933-03-8
m-tolylboronic acid

: 1339075-32-9
diethyl (3-(N-(benzyloxy)acetamido)-1-(3'-methyl-[1,1'-biphenyl]-4-yl)propyl)phosphonate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,2-dimethoxyethane; water; at 100 ℃; for 0.25h; Microwave irradiation; Sealed tube;
DOI:10.1021/jo201715x

Reference yield:

: 1339075-20-5
diethyl (1-(4-bromophenyl)-3-oxopropyl)phosphonate

: 1339075-32-9
diethyl (3-(N-(benzyloxy)acetamido)-1-(3'-methyl-[1,1'-biphenyl]-4-yl)propyl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / ethanol / 5 h

2.1: sodium cyanoborohydride / methanol / 20 °C

2.2: 0 °C / Cooling with ice

3.1: triethylamine / dichloromethane / 1.5 h

4.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / Microwave irradiation; Sealed tube

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium cyanoborohydride; potassium carbonate; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 4.1: Suzuki coupling;
DOI:10.1021/jo201715x

Reference yield:

: C₂₀H₂₅BrNO₄P

: 1339075-32-9
diethyl (3-(N-(benzyloxy)acetamido)-1-(3'-methyl-[1,1'-biphenyl]-4-yl)propyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium cyanoborohydride / methanol / 20 °C

1.2: 0 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 1.5 h

3.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / Microwave irradiation; Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; sodium cyanoborohydride; potassium carbonate; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In methanol; 1,2-dimethoxyethane; dichloromethane; water; 3.1: Suzuki coupling;
DOI:10.1021/jo201715x