(3R,4R,5R)-2-benzyl-3-ethoxycarbonyl-4-hydroxymethyl-3,5-dimethylisoxazolidine

Base Information

Chemical Name:(3R,4R,5R)-2-benzyl-3-ethoxycarbonyl-4-hydroxymethyl-3,5-dimethylisoxazolidine
CAS No.:1373354-16-5
Molecular Formula:C₁₆H₂₃NO₄
Molecular Weight:293.363
Hs Code.:

Synonyms:(3R,4R,5R)-2-benzyl-3-ethoxycarbonyl-4-hydroxymethyl-3,5-dimethylisoxazolidine

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Chemical Property of (3R,4R,5R)-2-benzyl-3-ethoxycarbonyl-4-hydroxymethyl-3,5-dimethylisoxazolidine

Chemical Property:

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Technology Process of (3R,4R,5R)-2-benzyl-3-ethoxycarbonyl-4-hydroxymethyl-3,5-dimethylisoxazolidine

There total 4 articles about (3R,4R,5R)-2-benzyl-3-ethoxycarbonyl-4-hydroxymethyl-3,5-dimethylisoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373354-07-4
(3R,4S,5R)-ethyl 2-benzyl-4-formyl-3,5-dimethylisoxazolidine-3-carboxylate

: 1373354-16-5
(3R,4R,5R)-2-benzyl-3-ethoxycarbonyl-4-hydroxymethyl-3,5-dimethylisoxazolidine

Guidance literature:: (3R,4S,5R)-ethyl 2-benzyl-4-formyl-3,5-dimethylisoxazolidine-3-carboxylate; With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

With water; In methanol;
DOI:10.1016/j.tetasy.2012.02.003

Reference yield:

: 617-35-6
2-oxo-propionic acid ethyl ester

: 1373354-16-5
(3R,4R,5R)-2-benzyl-3-ethoxycarbonyl-4-hydroxymethyl-3,5-dimethylisoxazolidine

Guidance literature:: Multi-step reaction with 3 steps

2: (5R)-(+)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride; water / nitromethane / 22 h / 20 °C

3: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

With sodium tetrahydroborate; (5R)-(+)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride; water; In methanol; nitromethane;
DOI:10.1016/j.tetasy.2012.02.003

Reference yield:

: 29601-98-7
N-benzylhydroxylamine hydrochloride

: 1373354-16-5
(3R,4R,5R)-2-benzyl-3-ethoxycarbonyl-4-hydroxymethyl-3,5-dimethylisoxazolidine

Guidance literature:: Multi-step reaction with 3 steps

2: (5R)-(+)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride; water / nitromethane / 22 h / 20 °C

3: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

With sodium tetrahydroborate; (5R)-(+)-2,2,3-trimethyl-5-benzyl-4-imidazolidinone monohydrochloride; water; In methanol; nitromethane;
DOI:10.1016/j.tetasy.2012.02.003