N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-6-(4-methylpiperazin-1-yl)-4-phenylnicotinamide

Base Information

Chemical Name:N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-6-(4-methylpiperazin-1-yl)-4-phenylnicotinamide
CAS No.:1303445-81-9
Molecular Formula:C₂₇H₂₆F₆N₄O
Molecular Weight:536.52
Hs Code.:

Synonyms:N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-6-(4-methylpiperazin-1-yl)-4-phenylnicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-6-(4-methylpiperazin-1-yl)-4-phenylnicotinamide

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Technology Process of N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-6-(4-methylpiperazin-1-yl)-4-phenylnicotinamide

There total 7 articles about N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-6-(4-methylpiperazin-1-yl)-4-phenylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 109-01-3
1-methyl-piperazine

: 1303445-74-0
N-[3,5-bis(trifluoromethyl)benzyl]-6-chloro-2-methyl-4-phenylnicotinamide

: 1303445-81-9
N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-6-(4-methylpiperazin-1-yl)-4-phenylnicotinamide

Guidance literature:: at 140 ℃; for 20h;
DOI:10.1016/j.bmc.2011.02.031

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 1303445-81-9
N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-6-(4-methylpiperazin-1-yl)-4-phenylnicotinamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: piperidine / N,N-dimethyl-formamide / 1 h / Reflux

2.1: sodium hydroxide / ethanol / 6 h / Reflux

2.2: 0 - 5 °C / pH 5 - 6

3.1: thionyl chloride / 3 h / Reflux

4.1: triethylamine / dichloromethane / 1 h / Reflux

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 20 °C

6.1: trichlorophosphate / 3 h / Reflux

7.1: 20 h / 140 °C

With piperidine; thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.02.031

Reference yield:

: 1256643-39-6
2-methyl-4-phenylnicotinic acid

: 1303445-81-9
N-[3,5-bis(trifluoromethyl)benzyl]-2-methyl-6-(4-methylpiperazin-1-yl)-4-phenylnicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 3 h / Reflux

2: triethylamine / dichloromethane / 1 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 20 °C

4: trichlorophosphate / 3 h / Reflux

5: 20 h / 140 °C

With thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; chloroform;
DOI:10.1016/j.bmc.2011.02.031