2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

Base Information

• Chemical Name: 2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine
• CAS No.: 1278593-92-2
• Molecular Formula: C₅₄H₅₇N₁₂O₉P
• Molecular Weight: 1049.1

Synonyms:2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

Chemical Property of 2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

There total 2 articles about 2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2'-(4-(N6-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine (1278593-91-1) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 2'-(4-(N6-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine (1278593-92-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c0ob00438c

Reference yield:

N6-benzoyl-N9-propargyladenine (1278593-88-6) + 2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine (177980-10-8) → 2'-(4-(N6-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine (1278593-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tetrahydrofuran; pyridine; water / 16 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; dichloromethane; water;

DOI:10.1039/c0ob00438c

upstream raw materials:

N₆-benzoyl-N₉-propargyladenine

2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1278593-92-2 2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send