METHYL 2-AMINO-6-METHOXYPYRIDINE-3-CARBOXYLATE

Base Information

• Chemical Name: METHYL 2-AMINO-6-METHOXYPYRIDINE-3-CARBOXYLATE
• CAS No.: 1227048-93-2
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.179
• Mol file: 1227048-93-2.mol

Synonyms:methyl 2-amino-6-methoxynicotinate

Chemical Property of METHYL 2-AMINO-6-METHOXYPYRIDINE-3-CARBOXYLATE

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-6-methoxy-nicotinicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL 2-AMINO-6-METHOXYPYRIDINE-3-CARBOXYLATE

There total 6 articles about METHYL 2-AMINO-6-METHOXYPYRIDINE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 6-methoxy-2-((4-methoxybenzyl)amino)nicotinate (1298123-87-1) → methyl 2-amino-6-methoxynicotinate (1227048-93-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 27 ℃; for 16h; Inert atmosphere;

Reference yield:

2-chloro-6-methoxypyridine-3-carboxylic acid (503000-87-1) → methyl 2-amino-6-methoxynicotinate (1227048-93-2)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 16 h / 0 - 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 0 - 100 °C

3: palladium on activated charcoal; hydrogen / ethanol / 16 h / 27 °C / Inert atmosphere

With thionyl chloride; palladium on activated charcoal; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

methyl 6-methoxy-2-(benzylamino)nicotinate (1298123-78-0) → methyl 2-amino-6-methoxynicotinate (1227048-93-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 70 ℃;

DOI:10.1055/s-0030-1259283

upstream raw materials:

methyl 6-methoxy-2-(benzylamino)nicotinate

methyl 6-methoxy-2-((4-methoxybenzyl)amino)nicotinate

2,6-dichloropyridine-3-carboxylic acid

2-chloro-6-methoxypyridine-3-carboxylic acid

Downstream raw materials:

2-amino-6-methoxynicotinic acid