(4S,4aS,7R,8aR)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-4a-formyl-2-hydroxy-7-isopropenyl-5-oxo-3,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid allyl ester

Base Information

Chemical Name:(4S,4aS,7R,8aR)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-4a-formyl-2-hydroxy-7-isopropenyl-5-oxo-3,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid allyl ester
CAS No.:872525-82-1
Molecular Formula:C₄₅H₅₆O₉Si
Molecular Weight:769.02
Hs Code.:

(4S,4aS,7R,8aR)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-4a-formyl-2-hydroxy-7-isopropenyl-5-oxo-3,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid allyl ester

Synonyms:(4S,4aS,7R,8aR)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-4a-formyl-2-hydroxy-7-isopropenyl-5-oxo-3,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid allyl ester

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Chemical Property of (4S,4aS,7R,8aR)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-4a-formyl-2-hydroxy-7-isopropenyl-5-oxo-3,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid allyl ester

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Technology Process of (4S,4aS,7R,8aR)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-4a-formyl-2-hydroxy-7-isopropenyl-5-oxo-3,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid allyl ester

There total 7 articles about (4S,4aS,7R,8aR)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-4a-formyl-2-hydroxy-7-isopropenyl-5-oxo-3,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 872525-97-8
(R)-4-Isopropenyl-6-oxo-cyclohex-1-enecarbaldehyde

: 493021-03-7
(E)-(R)-6-Acetoxy-7-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-3-oxo-hept-4-enoic acid allyl ester

: 872525-82-1
(4S,4aS,7R,8aR)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-4a-formyl-2-hydroxy-7-isopropenyl-5-oxo-3,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid allyl ester

Guidance literature:: With caesium carbonate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1139/v05-042

Reference yield:

: 859843-12-2
(5R)-2-hydroxymethyl-5-isopropenyl-cyclohex-2-enone

: 872525-82-1
(4S,4aS,7R,8aR)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-4a-formyl-2-hydroxy-7-isopropenyl-5-oxo-3,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

2: 22 percent / cesium carbonate / CH₂Cl₂ / 2 h / 20 °C

With caesium carbonate; Dess-Martin periodane; In dichloromethane;
DOI:10.1139/v05-042

Reference yield:

: 872525-75-2
(R)-4-(2,2-Dimethoxy-ethyl)-5-methyl-hex-5-en-2-one

: 872525-82-1
(4S,4aS,7R,8aR)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-4a-formyl-2-hydroxy-7-isopropenyl-5-oxo-3,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / acetic acid / H₂O / 40 °C

2: p-toluenesulfonic acid / toluene / 100 °C

3: 54 percent / 4-dimethylaminopyridine / tetrahydrofuran / 16 h / 60 °C

4: 83 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

5: 22 percent / cesium carbonate / CH₂Cl₂ / 2 h / 20 °C

With dmap; caesium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; dichloromethane; water; toluene; 3: Baylis-Hillman reaction;
DOI:10.1139/v05-042