1-(2,4-dichlorophenyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:1-(2,4-dichlorophenyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide
CAS No.:1609564-68-2
Molecular Formula:C₂₈H₂₆Cl₂N₄O₄S
Molecular Weight:585.511
Hs Code.:

Synonyms:1-(2,4-dichlorophenyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

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Chemical Property of 1-(2,4-dichlorophenyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

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Technology Process of 1-(2,4-dichlorophenyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

There total 4 articles about 1-(2,4-dichlorophenyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 114500-32-2
4-methyl-3-(morpholine-4-sulfonyl)phenylamine

: 1609564-63-7
1-(2,4-dichlorophenyl)-3-p-tolyl-1H-pyrazole-4-carboxylic acid

: 1609564-68-2
1-(2,4-dichlorophenyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Guidance literature:: 1-(2,4-dichlorophenyl)-3-p-tolyl-1H-pyrazole-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 1h; Inert atmosphere;

4-methyl-3-(morpholine-4-sulfonyl)phenylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.014

Reference yield:

: 1609564-59-1
1-(2,4-dichlorophenyl)-3-p-tolyl-1H-pyrazole-4-carbaldehyde

: 1609564-68-2
1-(2,4-dichlorophenyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Jones reagent / acetone / 20 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

With Jones reagent; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone; 2.1: |Mitsunobu Displacement / 2.2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2014.04.014

Reference yield:

: 122-00-9
para-methylacetophenone

: 1609564-68-2
1-(2,4-dichlorophenyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol; water / 18 h / 20 °C / Inert atmosphere

2.1: trichlorophosphate / chloroform-d1 / 18 h / 70 °C / Inert atmosphere; Cooling with ice

3.1: Jones reagent / acetone / 20 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

With Jones reagent; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In methanol; chloroform-d1; dichloromethane; water; acetone; 4.1: |Mitsunobu Displacement / 4.2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2014.04.014