Methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate

Base Information

Chemical Name:Methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate
CAS No.:1191413-53-2
Molecular Formula:C₃₅H₃₇N₃O₅
Molecular Weight:579.696
Hs Code.:

Methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate

Synonyms:Methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate

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Chemical Property of Methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate

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Technology Process of Methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate

There total 6 articles about Methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1191413-20-3
methyl 4-amino-2-methyl-2,3-dihydro-1H-indene-2-carboxylate

: 1191413-06-5
cyclopentyl (4-{[2-(4-fluorophenyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]methyl}phenyl)acetic acid

: 1191413-53-2
Methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: With pyridine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 379257-42-8
ethyl 4-methoxy-2-methylindan-2-carboxylate

: 1191413-53-2
Methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: boron tribromide / dichloromethane / 1 h / 0 °C

2: pyridine / 2 h / -15 - 20 °C

3: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 100 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

5: pyridine; HATU / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogen; boron tribromide; caesium carbonate; HATU; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In 1,4-dioxane; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1191413-19-0
methyl 4-(benzylamino)-2-methyl-2,3-dihydro-1H-indene-2-carboxylate

: 1191413-53-2
Methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

2: pyridine; HATU / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogen; HATU; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;