Technology Process of ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-methyl-1H-indazol-1-yl]butanoate
There total 17 articles about ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-methyl-1H-indazol-1-yl]butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-cyano-4-isopropoxybenzoic acid;
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.166667h;
ethyl 4-{5-[(hydroxyamino)(imino)methyl]-6-methyl-1H-indazol-1-yl}butanoate;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tert.-butylnitrite; potassium acetate / 18-crown-6 ether / chloroform / 20 h / 75 °C
1.2: 0.08 h
2.1: hydrogenchloride; water / methanol / 2 h / 50 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C
4.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 20 h / 120 °C / Inert atmosphere
5.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 41.5 h / 60 - 100 °C
6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C
6.2: 18 h / 80 °C
With
hydrogenchloride; tert.-butylnitrite; hydroxylamine hydrochloride; water; potassium acetate; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
tetrakis(triphenylphosphine) palladium(0); 18-crown-6 ether;
In
methanol; ethanol; chloroform; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 20 h / 120 °C / Inert atmosphere
3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 41.5 h / 60 - 100 °C
4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C
4.2: 18 h / 80 °C
With
hydroxylamine hydrochloride; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; N,N-dimethyl-formamide;
