(1R)-1-{1-[(3S)-1-(3-phenylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol

Base Information

Chemical Name:(1R)-1-{1-[(3S)-1-(3-phenylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol
CAS No.:1607591-86-5
Molecular Formula:C₂₄H₂₆N₄O₂S
Molecular Weight:434.562
Hs Code.:

Synonyms:(1R)-1-{1-[(3S)-1-(3-phenylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol

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Chemical Property of (1R)-1-{1-[(3S)-1-(3-phenylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol

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Technology Process of (1R)-1-{1-[(3S)-1-(3-phenylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol

There total 7 articles about (1R)-1-{1-[(3S)-1-(3-phenylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1607591-78-5
(1R)-1-{1-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol hydrochloride

: 645-45-4
hydrocinnamic acid chloride

: 1607591-86-5
(1R)-1-{1-[(3S)-1-(3-phenylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607591-86-5
(1R)-1-{1-[(3S)-1-(3-phenylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: triethylamine / isopropyl alcohol / 2 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol

5.1: triethyloxonium fluoroborate / tetrahydrofuran / 1.25 h / 20 °C

5.2: 2 h / 80 °C

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

7.1: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; tetrabutylammonium nitrate; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 110651-92-8
7-chloro-6-nitrothieno[3,2-b]pyridine

: 1607591-86-5
(1R)-1-{1-[(3S)-1-(3-phenylpropanoyl)piperidin-3-yl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / isopropyl alcohol / 2 h / 90 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol

3.1: triethyloxonium fluoroborate / tetrahydrofuran / 1.25 h / 20 °C

3.2: 2 h / 80 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

5.1: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;