[4-(5-bromo-2-methyl-benzofuran-3-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone

Base Information

Chemical Name:[4-(5-bromo-2-methyl-benzofuran-3-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone
CAS No.:1443755-80-3
Molecular Formula:C₂₅H₂₃BrFN₅O₃
Molecular Weight:540.392
Hs Code.:

Synonyms:[4-(5-bromo-2-methyl-benzofuran-3-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [4-(5-bromo-2-methyl-benzofuran-3-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [4-(5-bromo-2-methyl-benzofuran-3-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone

There total 6 articles about [4-(5-bromo-2-methyl-benzofuran-3-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1443759-35-0
(2,2-dimethyl-piperazin-1-yl)-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone

: 1443759-58-7
5-bromo-2-methyl-benzofuran-3-carboxylic acid

: 1443755-80-3
[4-(5-bromo-2-methyl-benzofuran-3-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 89284-52-6
1,4-dibromo-2-iodo-benzene

: 1443755-80-3
[4-(5-bromo-2-methyl-benzofuran-3-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; potassium carbonate / tetrahydrofuran / 5 h / 100 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran / 12 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 12 h / 20 °C

With copper(l) iodide; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 3638-73-1
2,5-dibromoaniline

: 1443755-80-3
[4-(5-bromo-2-methyl-benzofuran-3-carbonyl)-2,2-dimethyl-piperazin-1-yl]-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium nitrite; sulfuric acid; potassium iodide / water / 0 - 65 °C

2: copper(l) iodide; potassium carbonate / tetrahydrofuran / 5 h / 100 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 12 h / 60 °C

4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 12 h / 20 °C

With copper(l) iodide; sulfuric acid; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium iodide; lithium hydroxide; sodium nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide;