(2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid

Base Information

Chemical Name:(2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid
CAS No.:161153-16-8
Molecular Formula:C₁₅H₁₉NO₅S
Molecular Weight:325.386
Hs Code.:

Synonyms:(2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid

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Chemical Property of (2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid

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Technology Process of (2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid

There total 3 articles about (2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 201942-90-7
(2RS,4R)-2-(2-hydroxy-phenyl)-thiazolidine-4-carboxylic acid

: 24424-99-5
di-tert-butyl dicarbonate

: (2S,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid

: 161153-16-8
(2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid

Guidance literature:: (2RS,4R)-2-(2-hydroxy-phenyl)-thiazolidine-4-carboxylic acid; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 - 5 ℃; for 1.5h;

di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 20 ℃; for 12h;
DOI:10.1080/17415993.2016.1156116

Reference yield: 84.0%

: 24424-99-5
di-tert-butyl dicarbonate

: (2R,4R)-2-(2-hydroxyphenyl)thiazolidine-4-carboxylic acid

: 161153-16-8
(2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 18h; Ambient temperature;
DOI:10.1002/jhet.5570310608

Reference yield:

: 90-02-8
salicylaldehyde

: (2S,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid

: 161153-16-8
(2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-thiazolidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / water; dimethyl sulfoxide / 20 °C

2.1: sodium hydrogencarbonate / water; 1,4-dioxane / 1.5 h / 0 °C

2.2: 12 h / 0 - 20 °C

With sodium hydrogencarbonate; In 1,4-dioxane; water; dimethyl sulfoxide;
DOI:10.1039/c7nj02961f