N-Benzyl-C,C,C-trifluoro-N-trimethylsilanylethynyl-methanesulfonamide

Base Information

• Chemical Name: N-Benzyl-C,C,C-trifluoro-N-trimethylsilanylethynyl-methanesulfonamide
• CAS No.: 205885-30-9
• Molecular Formula: C₁₃H₁₆F₃NO₂SSi
• Molecular Weight: 335.422
• Mol file: 205885-30-9.mol

Synonyms:N-Benzyl-C,C,C-trifluoro-N-trimethylsilanylethynyl-methanesulfonamide

Chemical Property of N-Benzyl-C,C,C-trifluoro-N-trimethylsilanylethynyl-methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyl-C,C,C-trifluoro-N-trimethylsilanylethynyl-methanesulfonamide

There total 1 articles about N-Benzyl-C,C,C-trifluoro-N-trimethylsilanylethynyl-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-benzyl-1,1,1-trifluoromethanesulfonamide (36457-58-6) + phenyl(trimethylsilylethynyl)iodonium triflate (133816-00-9) → N-Benzyl-C,C,C-trifluoro-N-trimethylsilanylethynyl-methanesulfonamide (205885-30-9)

Guidance literature:

With n-butyllithium; In hexane; toluene; 1.) 0 to 20 deg C, 2.) 20 deg C, 12 h;

Reference yield:

N-Benzyl-C,C,C-trifluoro-N-trimethylsilanylethynyl-methanesulfonamide (205885-30-9) → N-Benzyl-N-ethynyl-C,C,C-trifluoro-methanesulfonamide

Guidance literature:

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Yield given;

Reference yield:

N-Benzyl-C,C,C-trifluoro-N-trimethylsilanylethynyl-methanesulfonamide (205885-30-9) → N-benzyl-C,C,C-trifluoro-N-(1-oxo-3a,4,5,6,7,7a-hexahydro-1H-4,7-methano-inden-2-yl)-methanesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂O; TBAF / tetrahydrofuran

2.1: tetrahydrofuran / 20 °C

2.2: 64 percent / trimethylamine N-oxide dihydrate / tetrahydrofuran; methanol / 20 °C

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; 1.1: Hydrolysis / 2.1: Metallation / 2.2: Cycloaddition;

upstream raw materials:

N-benzyl-1,1,1-trifluoromethanesulfonamide

phenyl(trimethylsilylethynyl)iodonium triflate